Literature DB >> 21052076

The future of genetic research on neurodegeneration.

Christine Van Broeckhoven1.   

Abstract

Why, with all the progress in the field of neurodegeneration, do we still lack disease-modifying drugs that tackle the primary defect of severe cell loss? How much progress has been made toward this goal? Have we spent our time and resources wisely? And, most important, is there room for improvement? This commentary highlights several problems faced by researchers in studying the genetic etiology of neurodegenerative diseases and seeks to provide direction in overcoming some of these obstacles.

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Year:  2010        PMID： 21052076     DOI： 10.1038/nm.2225

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  47 in total

Review 1.  Alzheimer's disease: one disorder, too many genes?

Authors:  Lars Bertram; Rudolph E Tanzi
Journal:  Hum Mol Genet       Date:  2004-02-05       Impact factor: 6.150

2.  Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.

Authors:  Marc Cruts; Ilse Gijselinck; Julie van der Zee; Sebastiaan Engelborghs; Hans Wils; Daniel Pirici; Rosa Rademakers; Rik Vandenberghe; Bart Dermaut; Jean-Jacques Martin; Cornelia van Duijn; Karin Peeters; Raf Sciot; Patrick Santens; Tim De Pooter; Maria Mattheijssens; Marleen Van den Broeck; Ivy Cuijt; Krist'l Vennekens; Peter P De Deyn; Samir Kumar-Singh; Christine Van Broeckhoven
Journal:  Nature       Date:  2006-07-16       Impact factor: 49.962

3.  Frontotemporal dementia phenotype associated with MAPT gene duplication.

Authors:  Anne Rovelet-Lecrux; Didier Hannequin; Olivier Guillin; Solenn Legallic; Snejana Jurici; David Wallon; Thierry Frebourg; Dominique Campion
Journal:  J Alzheimers Dis       Date:  2010       Impact factor: 4.472

4.  Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels.

Authors:  John S K Kauwe; Carlos Cruchaga; Sarah Bertelsen; Kevin Mayo; Wayne Latu; Petra Nowotny; Anthony L Hinrichs; Anne M Fagan; David M Holtzman; Alison M Goate
Journal:  J Alzheimers Dis       Date:  2010       Impact factor: 4.472

Review 5.  Current status on Alzheimer disease molecular genetics: from past, to present, to future.

Authors:  Karolien Bettens; Kristel Sleegers; Christine Van Broeckhoven
Journal:  Hum Mol Genet       Date:  2010-04-13       Impact factor: 6.150

6.  A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques.

Authors:  Bart Dermaut; Samir Kumar-Singh; Sebastian Engelborghs; Jessie Theuns; Rosa Rademakers; Jos Saerens; Barbara A Pickut; Karin Peeters; Marleen van den Broeck; Krist'l Vennekens; Stephen Claes; Marc Cruts; Patrick Cras; Jean-Jacques Martin; Christine Van Broeckhoven; Peter Paul De Deyn
Journal:  Ann Neurol       Date:  2004-05       Impact factor: 10.422

Review 7.  Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.

Authors:  Karen Nuytemans; Jessie Theuns; Marc Cruts; Christine Van Broeckhoven
Journal:  Hum Mutat       Date:  2010-07       Impact factor: 4.878

8.  Pravastatin and cognitive function in the elderly. Results of the PROSPER study.

Authors:  Stella Trompet; Peter van Vliet; Anton J M de Craen; Jelle Jolles; Brendan M Buckley; Michael B Murphy; Ian Ford; Peter W Macfarlane; Naveed Sattar; Chris J Packard; David J Stott; Jim Shepherd; Eduard L E M Bollen; Gerard J Blauw; J Wouter Jukema; Rudi G J Westendorp
Journal:  J Neurol       Date:  2009-08-04       Impact factor: 4.849

9.  Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease.

Authors:  M A Nalls; R J Guerreiro; J Simon-Sanchez; J T Bras; B J Traynor; J R Gibbs; L Launer; J Hardy; A B Singleton
Journal:  Neurogenetics       Date:  2009-03-07       Impact factor: 2.660

10.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

Authors:  R Sherrington; E I Rogaev; Y Liang; E A Rogaeva; G Levesque; M Ikeda; H Chi; C Lin; G Li; K Holman; T Tsuda; L Mar; J F Foncin; A C Bruni; M P Montesi; S Sorbi; I Rainero; L Pinessi; L Nee; I Chumakov; D Pollen; A Brookes; P Sanseau; R J Polinsky; W Wasco; H A Da Silva; J L Haines; M A Perkicak-Vance; R E Tanzi; A D Roses; P E Fraser; J M Rommens; P H St George-Hyslop
Journal:  Nature       Date:  1995-06-29       Impact factor: 49.962
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  8 in total

Review 1.  Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.

Authors:  Berislav V Zlokovic
Journal:  Nat Rev Neurosci       Date:  2011-11-03       Impact factor: 34.870

Review 2.  Genetics of dementia.

Authors:  Henry L Paulson; Indu Igo
Journal:  Semin Neurol       Date:  2012-01-21       Impact factor: 3.420

3.  Learning from genetic forms of neurodegeneration.

Authors:  Alexis Brice
Journal:  Nat Med       Date:  2010-12       Impact factor: 53.440

4.  Neurodegeneration and the neurovascular unit.

Authors:  Berislav V Zlokovic
Journal:  Nat Med       Date:  2010-12       Impact factor: 53.440

5.  Neurodegeneration and the neuroimmune system.

Authors:  Joseph El Khoury
Journal:  Nat Med       Date:  2010-12       Impact factor: 53.440

Review 6.  De novo mutations, genetic mosaicism and human disease.

Authors:  Mohiuddin Mohiuddin; R Frank Kooy; Christopher E Pearson
Journal:  Front Genet       Date:  2022-09-26       Impact factor: 4.772

7.  Con: Alzheimer's disease and circadian dysfunction: chicken or egg?

Authors:  Abhay Moghekar; Richard J O'Brien
Journal:  Alzheimers Res Ther       Date:  2012-08-13       Impact factor: 6.982

8.  Somatic alpha-synuclein mutations in Parkinson's disease: hypothesis and preliminary data.

Authors:  Christos Proukakis; Henry Houlden; Anthony H Schapira
Journal:  Mov Disord       Date:  2013-05-14       Impact factor: 10.338
  8 in total

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