Literature DB >> 1303197

Identification and characterization of a new gene in the human Xq28 region.

A M van den Ouweland1, P Kioschis, M Verdijk, F Tamanini, D Toniolo, A Poustka, B A van Oost.   

Abstract

A human Xqter chromosome cosmid library was screened with a mixed probe derived from porcine kidney mRNA. A new expressed gene was identified in a cosmid clone known to be part of a G6PD cosmid contig. This gene is most likely a housekeeping gene because the cDNA clone recognizes a 1 kb mRNA transcript in all cell lines and tissues tested. Hybridizing genomic DNA of several species with a cDNA probe indicated that the gene is highly conserved during evolution and that it belongs to a gene family. The genomic sequence shows a 100% homology with the recently identified QM cDNA sequence.

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Year:  1992        PMID: 1303197     DOI: 10.1093/hmg/1.4.269

Source DB:  PubMed          Journal:  Hum Mol Genet        ISSN: 0964-6906            Impact factor:   6.150


  7 in total

1.  Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes.

Authors:  C M Smith; J A Steitz
Journal:  Mol Cell Biol       Date:  1998-12       Impact factor: 4.272

2.  Isolation and characterization of the QM promoter.

Authors:  A A Farmer; J I Johnsen; T M Loftus; K P Smith; E J Stanbridge
Journal:  Nucleic Acids Res       Date:  1996-06-01       Impact factor: 16.971

3.  Identification of tissue-specific expressed sequences in human band Xq28 with complex pig cDNA probes.

Authors:  J F Coy; P Kioschis; Z Sedlacek; A Poustka
Journal:  Mamm Genome       Date:  1994-03       Impact factor: 2.957

4.  A Jun-binding protein related to a putative tumor suppressor.

Authors:  F S Monteclaro; P K Vogt
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205

5.  Direct selection of DNA sequences conserved between species.

Authors:  Z Sedlacek; D S Konecki; R Siebenhaar; P Kioschis; A Poustka
Journal:  Nucleic Acids Res       Date:  1993-07-25       Impact factor: 16.971

6.  Evolutionary conservation and genomic organization of XAP-4, an Xq28 located gene coding for a human rab GDP-dissociation inhibitor (GDI).

Authors:  Z Sedlacek; D S Konecki; B Korn; S M Klauck; A Poustka
Journal:  Mamm Genome       Date:  1994-10       Impact factor: 2.957

7.  Transcriptional organization of a 450-kb region of the human X chromosome in Xq28.

Authors:  S Bione; F Tamanini; E Maestrini; C Tribioli; A Poustka; G Torri; S Rivella; D Toniolo
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205

  7 in total

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