Literature DB >> 8341691

A Jun-binding protein related to a putative tumor suppressor.

F S Monteclaro1, P K Vogt.   

Abstract

A lambda gt11 cDNA library of chicken embryo fibroblasts was screened with biotinylated Jun protein to identify Jun-binding clones. Eight such clones were isolated; one contains a gene referred to as jif-1 that is homologous to the putative tumor suppressor gene QM. jif-1 codes for a protein of 25 kDa that binds to the leucine zipper of viral and cellular Jun. The Jif-1 protein also binds to itself. Jif-1 does not contain a leucine zipper, and it does not bind to the 12-O-tetradecanoylphorbol 13-acetate response element DNA sequence. Complex formation of Jif-1 with Jun inhibits DNA binding and reduces transactivation by Jun. Addition of Fos protein to Jun-Jif-1 complexes restores DNA-binding activity. These observations suggest that Jif-1 is a negative regulator of Jun.

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Year:  1993        PMID： 8341691      PMCID： PMC47005          DOI： 10.1073/pnas.90.14.6726

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  43 in total

1.  Functional antagonism between c-Jun and MyoD proteins: a direct physical association.

Authors:  E Bengal; L Ransone; R Scharfmann; V J Dwarki; S J Tapscott; H Weintraub; I M Verma
Journal:  Cell       Date:  1992-02-07       Impact factor: 41.582

2.  cDNA cloning and genomic analysis of a new multigene family sharing common phylogenetic and expression profiles with the laminin receptor gene.

Authors:  C Bignon; M Roux-Dosseto; M E Zeigler; M S Wicha; P M Martin
Journal:  Biochem Biophys Res Commun       Date:  1992-05-15       Impact factor: 3.575

Review 3.  More is better: activators and repressors from the same gene.

Authors:  N S Foulkes; P Sassone-Corsi
Journal:  Cell       Date:  1992-02-07       Impact factor: 41.582

4.  Mutations in the Jun delta region suggest an inverse correlation between transformation and transcriptional activation.

Authors:  L S Håvarstein; I M Morgan; W Y Wong; P K Vogt
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-15       Impact factor: 11.205

5.  Insulin-like growth factor-1 induces tyrosyl phosphorylation of nuclear proteins.

Authors:  B S Oemar; N M Law; S A Rosenzweig
Journal:  J Biol Chem       Date:  1991-12-25       Impact factor: 5.157

6.  Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.

Authors:  V Adler; C C Franklin; A S Kraft
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

7.  The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells.

Authors:  S F Dowdy; K M Lai; B E Weissman; Y Matsui; B L Hogan; E J Stanbridge
Journal:  Nucleic Acids Res       Date:  1991-10-25       Impact factor: 16.971

8.  Protein phosphatase 2A reverses phosphorylation of c-Jun specified by the delta domain in vitro: correlation with oncogenic activation and deregulated transactivation activity of v-Jun.

Authors:  E J Black; A J Street; D A Gillespie
Journal:  Oncogene       Date:  1991-11       Impact factor: 9.867

9.  Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.

Authors:  L Li; J C Chambard; M Karin; E N Olson
Journal:  Genes Dev       Date:  1992-04       Impact factor: 11.361

10.  Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

Authors:  S Xanthoudakis; T Curran
Journal:  EMBO J       Date:  1992-02       Impact factor: 11.598
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  24 in total

1.  Cytoplasmic c-Jun N-terminal immunoreactivity: a hallmark of retinal apoptosis.

Authors:  Luciana B Chiarini; Fabíola G de Freitas; Mona Lisa Leal-Ferreira; Aviva Tolkovsky; Rafael Linden
Journal:  Cell Mol Neurobiol       Date:  2002-12       Impact factor: 5.046

2.  Tomato QM-like protein protects Saccharomyces cerevisiae cells against oxidative stress by regulating intracellular proline levels.

Authors:  Changbin Chen; Srimevan Wanduragala; Donald F Becker; Martin B Dickman
Journal:  Appl Environ Microbiol       Date:  2006-06       Impact factor: 4.792

3.  Molecular analysis of the QM gene from Penaeus monodon and its expression on the different ovarian stages of development.

Authors:  FaLin Zhou; ShiGui Jiang; JianHua Huang; LiHua Qiu; DianChang Zhang; TiannFeng Su
Journal:  Mol Biol Rep       Date:  2010-09-25       Impact factor: 2.316

4.  Isolation and characterization of the QM promoter.

Authors:  A A Farmer; J I Johnsen; T M Loftus; K P Smith; E J Stanbridge
Journal:  Nucleic Acids Res       Date:  1996-06-01       Impact factor: 16.971

5.  New evidence for differential roles of l10 ribosomal proteins from Arabidopsis.

Authors:  María Lorena Falcone Ferreyra; Romina Casadevall; Marianela Dana Luciani; Alejandro Pezza; Paula Casati
Journal:  Plant Physiol       Date:  2013-07-25       Impact factor: 8.340

6.  Modulation of MLC-2v gene expression by AP-1: complex regulatory role of Jun in cardiac myocytes.

Authors:  S K Goswami; S Shafiq; M A Siddiqui
Journal:  Mol Cell Biochem       Date:  2001-01       Impact factor: 3.396

7.  Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.

Authors:  A Aronheim; E Zandi; H Hennemann; S J Elledge; M Karin
Journal:  Mol Cell Biol       Date:  1997-06       Impact factor: 4.272

8.  Arabidopsis L10 ribosomal proteins in UV-B responses.

Authors:  María Lorena Falcone Ferreyra; Jordane Biarc; Alma L Burlingame; Paula Casati
Journal:  Plant Signal Behav       Date:  2010-10-01

Review 9.  Inactivation of X-linked tumor suppressor genes in human cancer.

Authors:  Runhua Liu; Mandy Kain; Lizhong Wang
Journal:  Future Oncol       Date:  2012-04       Impact factor: 3.404

10.  Molecular cloning and expression of a pearl oyster (Pinctada fucata) homologue of mammalian putative tumor suppressor QM.

Authors:  Yong Zhang; Jie Huang; Qingxiong Meng; Tiemin Jiang; Liping Xie; Zhao Wang; Rongqing Zhang
Journal:  Mar Biotechnol (NY)       Date:  2003-09-29       Impact factor: 3.619
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