| Literature DB >> 130137 |
A D Morris, J Esterly, G Chase, G C Sharp.
Abstract
Regular administration of cyclophosphamide to NZB/NZW female mice effectively protects against the nephritis that is thought to be a model for human SLE nephritis. Reductions in serologic, histologic, and immunogluorescent parameters of the disease are correlated. Intermittent as well as continuous administration of the drug is effective without the development of leukopenia. Possible mechanisms of drug action and a modified approach to therapy of immune complex disease are discussed.Entities:
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Year: 1976 PMID： 130137 DOI： 10.1002/art.1780190108
Source DB: PubMed Journal: Arthritis Rheum ISSN： 0004-3591