| Literature DB >> 742560 |
Abstract
Mice exhibiting a spontaneous SLE-like lethal autoimmunity (female NZB/W hybrids) were given monthly doses of cyclophosphamide (CPA) 240 mg/kg p.o. starting at four months of age. Antibodies to DNA and sheep red blood cells (SRBC) were measured as well as general well being of the mice. The CPA-treated group demonstrated a marked increased in survival compared to the untreated controls with reduction of anti-DNA antibody levels but only a slight inhibition of the anamnestic response to SRBC immunization.Entities:
Mesh：
Substances：
Year: 1978 PMID： 742560 DOI： 10.1007/bf01998895
Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299