Literature DB >> 6607142

Murine lupus nephritis: effects of cyclophosphamide on circulating and tissue bound immunoreactants.

T Cavallo, K Graves, N A Granholm.   

Abstract

We investigated the effects of cyclophosphamide (Cy) on immunoreactants of plasma and kidney of mice with lupus nephritis. Cy therapy decreased plasma concentrations of IgG, but not the concentrations of anti-DNA antibodies, C3, and C1q reactive materials; in glomeruli deposits of immunoreactants were mesangial in location and decreased overall. Although Cy arrested the nephritis of NZB/W mice, the anti-DNA activity in the renal eluates was very low and comparable in untreated and in treated mice. Immune complex systems other than, or in addition to, DNA-anti-DNA are likely to play a role in the pathogenesis and course of murine lupus nephritis.

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Year:  1984        PMID： 6607142      PMCID： PMC1535780     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  33 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Accelerated appearance of neoplasms in female NZB/NZW mice treated with high-dose cyclophosphamide.

Authors:  S E Walker; M R Anver
Journal:  Arthritis Rheum       Date:  1979-12

3.  Therapeutic studies in NZB-W mice. II. Relative efficacy of azathioprine, cyclophosphamide and methylprednisolone.

Authors:  M C Gelfand; A D Steinberg
Journal:  Arthritis Rheum       Date:  1972 May-Jun

4.  Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors:  G Mancini; A O Carbonara; J F Heremans
Journal:  Immunochemistry       Date:  1965-09

5.  An enzymic method for the trace iodination of immunoglobulins and other proteins.

Authors:  J J Marchalonis
Journal:  Biochem J       Date:  1969-06       Impact factor: 3.857

6.  Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease. I. High avidity complexes and mesangiopathic glomerulonephritis.

Authors:  F G Germuth; E Rodriguez; C A Lorelle; E I Trump; L Milano; O Wise
Journal:  Lab Invest       Date:  1979-10       Impact factor: 5.662

7.  Effect of prostaglandin E on immune complex nephritis in NZB/W mice.

Authors:  V E Kelley; A Winkelstein; S Izui
Journal:  Lab Invest       Date:  1979-12       Impact factor: 5.662

8.  Glomerular permeability: focal loss of anionic sites in glomeruli of proteinuric mice with lupus nephritis.

Authors:  V E Kelley; T Cavallo
Journal:  Lab Invest       Date:  1980-01       Impact factor: 5.662

9.  Pathogenesis of the glomerulonephritis of NZB/W mice.

Authors:  P H Lambert; F J Dixon
Journal:  J Exp Med       Date:  1968-03-01       Impact factor: 14.307

10.  Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

Authors:  B S Andrews; R A Eisenberg; A N Theofilopoulos; S Izui; C B Wilson; P J McConahey; E D Murphy; J B Roths; F J Dixon
Journal:  J Exp Med       Date:  1978-11-01       Impact factor: 14.307
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  3 in total

1.  The effects of CP 17193, an immunosuppressive pyrazaloquinoline, on the development of spontaneous lupus disease in NZBW F1 hybrid mice.

Authors:  R V Bundick; R P Eady
Journal:  Clin Exp Immunol       Date:  1992-08       Impact factor: 4.330

2.  Cyclophosphamide and 15(S)-15 methyl PGE1 correct the T/B lymphocyte ratios of NZB/NZW mice.

Authors:  D Girard; R M Aloisi; M L Bliven; A C Cunningham; I G Otterness
Journal:  Agents Actions       Date:  1990-03

3.  Clinical amelioration of murine lupus by a peptide based on the complementarity determining region-1 of an autoantibody and by cyclophosphamide: similarities and differences in the mechanisms of action.

Authors:  Amir Sharabi; Hava Azulai; Zev M Sthoeger; Edna Mozes
Journal:  Immunology       Date:  2007-03-07       Impact factor: 7.397
  3 in total

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