BACKGROUND: Advanced glycation end products (AGEs) are thought to be involved in many complications of end-stage renal disease. This study analyzed serum AGE level reduction rates and corresponding long-term changes in serum levels among different dialysis modes. METHODS: Eighty-one patients with chronic uremia were divided into 3 groups receiving conventional hemodialysis (HD), high-flux HD, or on-line hemodiafiltration (HDF). Serum AGE levels were measured by competitive enzyme-linked immunosorbent assay predialysis and postdialysis and after 6 months. Additionally, AGE clearance was measured in 11 uremic patients treated with alternative high-flux HD and on-line HDF. RESULTS: Although predialysis serum AGE levels were similar, postdialysis levels were significantly lower in patients treated with on-line HDF (35.4 +/- 4.2 microg/mL) compared with those treated with conventional HD (82.2 +/- 11.4 microg/mL; P = 0.003), but not high-flux HD (56.7 +/- 5.9 microg/mL; P = 0.15). The serum AGE level reduction rate in on-line HDF (61.5% +/- 4.2%) was significantly greater than that in conventional HD (20.5% +/- 2.4%; P < 0.001) and high-flux HD patients (40.4% +/- 2.7%; P = 0.049). AGE clearance was increased 50% with on-line HDF compared with high-flux HD, reaching borderline significance (P = 0.07). In a 6-month study, predialysis serum AGE levels were significantly lower in patients treated with on-line HDF compared with those treated with conventional and high-flux HD. CONCLUSION: On-line HDF may provide an improved form of treatment that achieves significantly better AGE level reduction than high-flux HD and conventional HD. Uremic patients treated with on-line HDF for longer than 6 months achieved a significant reduction in predialysis serum AGE levels.
BACKGROUND: Advanced glycation end products (AGEs) are thought to be involved in many complications of end-stage renal disease. This study analyzed serum AGE level reduction rates and corresponding long-term changes in serum levels among different dialysis modes. METHODS: Eighty-one patients with chronic uremia were divided into 3 groups receiving conventional hemodialysis (HD), high-flux HD, or on-line hemodiafiltration (HDF). Serum AGE levels were measured by competitive enzyme-linked immunosorbent assay predialysis and postdialysis and after 6 months. Additionally, AGE clearance was measured in 11 uremicpatients treated with alternative high-flux HD and on-line HDF. RESULTS: Although predialysis serum AGE levels were similar, postdialysis levels were significantly lower in patients treated with on-line HDF (35.4 +/- 4.2 microg/mL) compared with those treated with conventional HD (82.2 +/- 11.4 microg/mL; P = 0.003), but not high-flux HD (56.7 +/- 5.9 microg/mL; P = 0.15). The serum AGE level reduction rate in on-line HDF (61.5% +/- 4.2%) was significantly greater than that in conventional HD (20.5% +/- 2.4%; P < 0.001) and high-flux HDpatients (40.4% +/- 2.7%; P = 0.049). AGE clearance was increased 50% with on-line HDF compared with high-flux HD, reaching borderline significance (P = 0.07). In a 6-month study, predialysis serum AGE levels were significantly lower in patients treated with on-line HDF compared with those treated with conventional and high-flux HD. CONCLUSION: On-line HDF may provide an improved form of treatment that achieves significantly better AGE level reduction than high-flux HD and conventional HD. Uremicpatients treated with on-line HDF for longer than 6 months achieved a significant reduction in predialysis serum AGE levels.
Authors: Andréa E M Stinghen; Ziad A Massy; Helen Vlassara; Gary E Striker; Agnès Boullier Journal: J Am Soc Nephrol Date: 2015-08-26 Impact factor: 10.121
Authors: S Arsov; L Trajceska; W van Oeveren; A J Smit; P Dzekova; B Stegmayr; A Sikole; G Rakhorst; R Graaff Journal: Eur J Clin Nutr Date: 2015-01-14 Impact factor: 4.016
Authors: E Lars Penne; Peter J Blankestijn; Michiel L Bots; Marinus A van den Dorpel; Muriel P Grooteman; Menso J Nubé; Ingeborg van der Tweel; Piet M Ter Wee Journal: Curr Control Trials Cardiovasc Med Date: 2005-05-20
Authors: Ayşe Ağbaş; Nur Canpolat; Salim Çalışkan; Alev Yılmaz; Hakan Ekmekçi; Mark Mayes; Helen Aitkenhead; Franz Schaefer; Lale Sever; Rukshana Shroff Journal: PLoS One Date: 2018-06-18 Impact factor: 3.240