Literature DB >> 12943422

Products of cytochrome P450(BioI) (CYP107H1)-catalyzed oxidation of fatty acids.

Max J Cryle1, Nick J Matovic, James J De Voss.   

Abstract

[reaction: see text] Oxidation of tetradecanoic and hexadecanoic acids by cytochrome P450(BioI) (CYP107H1) produces mainly the 11-, 12-, and 13-hydroxy C(14) fatty acids and the 11- to 15-hydroxy C(16) fatty acids, respectively. In contrast to previous reports, terminal hydroxylation is not observed. The enantiospecificity of fatty acid hydroxylation by P450(BioI) was also determined, and the enzyme was shown to be moderately selective for production of the (R)-alcohols.

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Year:  2003        PMID： 12943422     DOI： 10.1021/ol035254e

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

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Journal:  Nat Prod Rep       Date:  2012-07-23       Impact factor: 13.423

Review 2.  Synthesis of the α,ω-dicarboxylic acid precursor of biotin by the canonical fatty acid biosynthetic pathway.

Authors:  John E Cronan; Steven Lin
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Authors:  Irene Axarli; Ariadne Prigipaki; Nikolaos E Labrou
Journal:  Enzyme Res       Date:  2010-07-01

4.  Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.

Authors:  Max J Cryle; Ilme Schlichting
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-06       Impact factor: 11.205

5.  Importance of the long-chain fatty acid beta-hydroxylating cytochrome P450 enzyme YbdT for lipopeptide biosynthesis in Bacillus subtilis strain OKB105.

Authors:  Noha H Youssef; Neil Wofford; Michael J McInerney
Journal:  Int J Mol Sci       Date:  2011-03-08       Impact factor: 5.923

6.  Cytochrome P450 168A1 from Pseudomonas aeruginosa is involved in the hydroxylation of biologically relevant fatty acids.

Authors:  Claire L Price; Andrew G S Warrilow; Nicola J Rolley; Josie E Parker; Vera Thoss; Diane E Kelly; Nicolae Corcionivoschi; Steven L Kelly
Journal:  PLoS One       Date:  2022-03-21       Impact factor: 3.240
  6 in total

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