Literature DB >> 12930901

Genetic contributions to generalized arousal of brain and behavior.

J Garey1, A Goodwillie, J Frohlich, M Morgan, J-A Gustafsson, O Smithies, K S Korach, S Ogawa, D W Pfaff.   

Abstract

We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators, and mouse populations, it accounts for about 1/3 of the variance in arousal-related measures. Knockout of the gene coding for the classical estrogen receptor (ER-alpha), a ligand-activated transcription factor, greatly reduced arousal responses. In contrast, disrupting the gene for a likely gene duplication product, ER-beta, did not have these effects. A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance.

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Year:  2003        PMID： 12930901      PMCID： PMC196919          DOI： 10.1073/pnas.1633773100

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

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5.  Effects of estrogen on activity and fear-related behaviors in mice.

Authors:  M A Morgan; D W Pfaff
Journal:  Horm Behav       Date:  2001-12       Impact factor: 3.587

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8.  Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice.

Authors:  W Krezel; S Dupont; A Krust; P Chambon; P F Chapman
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  25 in total

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10.  Neuropeptidergic signaling partitions arousal behaviors in zebrafish.

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