Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Total synthesis of the proposed azaspiracid-1 structure, part 2: coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis.

Literature DB >> 12916037

Total synthesis of the proposed azaspiracid-1 structure, part 2: coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis.

K C Nicolaou¹, David Y-K Chen, Yiwei Li, Wenyuan Qian, Taotao Ling, Stepan Vyskocil, Theocharis V Koftis, Mugesh Govindasamy, Noriaki Uesaka.

Abstract

Entities: Chemical Gene

Mesh：

Substances：

Year: 2003 PMID： 12916037 DOI： 10.1002/anie.200351826

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

Keyword Cloud
Cited

× No keyword cloud information.

13 in total

1. Synthesis of the ABCD and ABCDE ring systems of azaspiracid-1.

Authors: Xiao-Ti Zhou; Rich G Carter
Journal: Chem Commun (Camb) Date: 2004-09-20 Impact factor: 6.222

Review 2. Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Authors: K C Nicolaou; Christopher R H Hale; Christian Nilewski; Heraklidia A Ioannidou
Journal: Chem Soc Rev Date: 2012-06-28 Impact factor: 54.564

3. Synthesis of the southern FGHI ring system of azaspiracid-1 and investigation into the controlling elements of C28- and C36-ketalization.

Authors: Xiao-Ti Zhou; Liang Lu; Daniel P Furkert; Charles E Wells; Rich G Carter
Journal: Angew Chem Int Ed Engl Date: 2006-11-20 Impact factor: 15.336

4. Synthesis of the C1-C26 northern portion of azaspiracid-1: kinetic versus thermodynamic control of the formation of the bis-spiroketal.

Authors: Xiao-Ti Zhou; Rich G Carter
Journal: Angew Chem Int Ed Engl Date: 2006-03-03 Impact factor: 15.336

9. Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons.

Authors: Carmen Vale; Kyriacos C Nicolaou; Michael O Frederick; Mercedes R Vieytes; Luis M Botana
Journal: Toxicol Sci Date: 2009-10-08 Impact factor: 4.849

10. Inspirations, discoveries, and future perspectives in total synthesis.

Authors: K C Nicolaou
Journal: J Org Chem Date: 2009-02-06 Impact factor: 4.354

Total synthesis of the proposed azaspiracid-1 structure, part 2: coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis.

1. Synthesis of the ABCD and ABCDE ring systems of azaspiracid-1.

Review 2. Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

3. Synthesis of the southern FGHI ring system of azaspiracid-1 and investigation into the controlling elements of C28- and C36-ketalization.

4. Synthesis of the C1-C26 northern portion of azaspiracid-1: kinetic versus thermodynamic control of the formation of the bis-spiroketal.

5. Total synthesis of atrochamins F, H, I, and J through cascade reactions.

6. Monoclonal antibodies with orthogonal azaspiracid epitopes.

7. Microsphere-based immunoassay for the detection of azaspiracids.

8. Azaspiracid substituent at C1 is relevant to in vitro toxicity.

9. Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons.

10. Inspirations, discoveries, and future perspectives in total synthesis.