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Literature DB >> 17044107

Synthesis of the southern FGHI ring system of azaspiracid-1 and investigation into the controlling elements of C28- and C36-ketalization.

Xiao-Ti Zhou¹, Liang Lu, Daniel P Furkert, Charles E Wells, Rich G Carter.

Abstract

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Year: 2006 PMID： 17044107 PMCID： PMC2414259 DOI： 10.1002/anie.200603353

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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23 in total

1. Synthesis of the (+)-C26-C40 Domain of the Azaspiracids by a Novel Double Intramolecular Hetero-Michael Addition Strategy This work was supported by the United States National Institute of Environmental Health Sciences (NIEHS; grant number ES10615), NIH, and by Bristol-Myers Squibb (CJF). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS, NIH, or BMS. We thank Dr. A. B. Dounay and Dr. G. Florence for critical reading of the manuscript.

Authors: Craig J. Forsyth; Junliang Hao; Josep Aiguade
Journal: Angew Chem Int Ed Engl Date: 2001-10-01 Impact factor: 15.336

2. A Versatile and High-Yield Route to Active and Well-Defined Catalysts

Authors: Jason A. Wiles; Steven H. Bergens; Koenraad P. M. Vanhessche; Daniel A. Dobbs; Valentin Rautenstrauch
Journal: Angew Chem Int Ed Engl Date: 2001-05-04 Impact factor: 15.336

3. Synthetic studies toward the C5-C20 domain of the azaspiracids.

Authors: A B Dounay; C J Forsyth
Journal: Org Lett Date: 2001-04-05 Impact factor: 6.005

4. Total synthesis of the proposed azaspiracid-1 structure, part 1: construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments.

Authors: K C Nicolaou; Yiwei Li; Noriaki Uesaka; Theocharis V Koftis; Stepan Vyskocil; Taotao Ling; Mugesh Govindasamy; Wenyuan Qian; Federico Bernal; David Y-K Chen
Journal: Angew Chem Int Ed Engl Date: 2003-08-11 Impact factor: 15.336

5. Synthesis of the ABCD and ABCDE ring systems of azaspiracid-1.

Authors: Xiao-Ti Zhou; Rich G Carter
Journal: Chem Commun (Camb) Date: 2004-09-20 Impact factor: 6.222

6. Synthesis of the azaspiracid-1 trioxadispiroketal.

Authors: Lisa K Geisler; Son Nguyen; Craig J Forsyth
Journal: Org Lett Date: 2004-11-11 Impact factor: 6.005

7. Total synthesis and confirmation of the revised structures of azaspiracid-2 and azaspiracid-3.

Authors: K C Nicolaou; Michael O Frederick; Goran Petrovic; Kevin P Cole; Eriketi Z Loizidou
Journal: Angew Chem Int Ed Engl Date: 2006-04-10 Impact factor: 15.336

8. Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product.

Authors: K C Nicolaou; David Y-K Chen; Yiwei Li; Noriaki Uesaka; Goran Petrovic; Theocharis V Koftis; Federico Bernal; Michael O Frederick; Mugesh Govindasamy; Taotao Ling; Petri M Pihko; Wenjun Tang; Stepan Vyskocil
Journal: J Am Chem Soc Date: 2006-02-22 Impact factor: 15.419

9. Synthesis of the ABC ring system of azaspiracid. 1. Effect of D ring truncation on bis-spirocyclization.

Authors: Rich G Carter; T Campbell Bourland; David E Graves
Journal: Org Lett Date: 2002-06-27 Impact factor: 6.005

10. Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin: asymmetric glycolate aldol reactions and biological evaluation.

Authors: Merritt B Andrus; Erik L Meredith; Erik J Hicken; Bryon L Simmons; Russell R Glancey; Wei Ma
Journal: J Org Chem Date: 2003-10-17 Impact factor: 4.354

5 in total

Synthesis of the southern FGHI ring system of azaspiracid-1 and investigation into the controlling elements of C28- and C36-ketalization.

2. A Versatile and High-Yield Route to Active and Well-Defined Catalysts

3. Synthetic studies toward the C5-C20 domain of the azaspiracids.

4. Total synthesis of the proposed azaspiracid-1 structure, part 1: construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments.

5. Synthesis of the ABCD and ABCDE ring systems of azaspiracid-1.

6. Synthesis of the azaspiracid-1 trioxadispiroketal.

7. Total synthesis and confirmation of the revised structures of azaspiracid-2 and azaspiracid-3.

8. Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product.

9. Synthesis of the ABC ring system of azaspiracid. 1. Effect of D ring truncation on bis-spirocyclization.

10. Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin: asymmetric glycolate aldol reactions and biological evaluation.

1. Total synthesis of cytotoxic macrolide amphidinolide B1 and the proposed structure of amphidinolide B2.

2. Amphidinolide B: total synthesis, structural investigation, and biological evaluation.

3. Nickel-Catalyzed Regiodivergent Approach to Macrolide Motifs.

4. Synthesis of the spiroiminal moiety and approaches to the synthesis of marineosins A and B.

5. Total synthesis of (+)-azaspiracid-1. An exhibition of the intricacies of complex molecule synthesis.