BACKGROUND: Several aspects of the relation between family history of ischemic heart disease (IHD) and risk of acute myocardial infarction (AMI) need further quantification. METHODS: A case-control study was conducted in Italy in 1995-1999 on 378 men and 129 women with a first nonfatal AMI, and 297 male and 181 female controls in a hospital for selected acute conditions. Odds ratios (OR) of AMI according to family history of IHD were estimated using unconditional logistic regression, adjusting for other AMI risk factors and family size. RESULTS: The overall OR for those having > or =1 first-degree relatives with IHD was 2.1, and 3.8 for > or =2 relatives. The OR for those with an affected parent or sibling were similar. The OR were also similar across strata of sex, age at diagnosis of the proband or the relative, and selected AMI risk factors, which were risk factors also in those with a positive family history. CONCLUSIONS: Family history of IHD is an independent risk factor for AMI, and intervention on modifiable risk factors may be beneficial also in those with a family history of the disease.
BACKGROUND: Several aspects of the relation between family history of ischemic heart disease (IHD) and risk of acute myocardial infarction (AMI) need further quantification. METHODS: A case-control study was conducted in Italy in 1995-1999 on 378 men and 129 women with a first nonfatal AMI, and 297 male and 181 female controls in a hospital for selected acute conditions. Odds ratios (OR) of AMI according to family history of IHD were estimated using unconditional logistic regression, adjusting for other AMI risk factors and family size. RESULTS: The overall OR for those having > or =1 first-degree relatives with IHD was 2.1, and 3.8 for > or =2 relatives. The OR for those with an affected parent or sibling were similar. The OR were also similar across strata of sex, age at diagnosis of the proband or the relative, and selected AMI risk factors, which were risk factors also in those with a positive family history. CONCLUSIONS: Family history of IHD is an independent risk factor for AMI, and intervention on modifiable risk factors may be beneficial also in those with a family history of the disease.
Authors: Dhananjay Vaidya; Lisa R Yanek; Taryn F Moy; Thomas A Pearson; Lewis C Becker; Diane M Becker Journal: Am J Cardiol Date: 2007-08-16 Impact factor: 2.778
Authors: Brian G Kral; Lewis C Becker; Dhananjay Vaidya; Lisa R Yanek; Rehan Qayyum; Stefan L Zimmerman; Damini Dey; Daniel S Berman; Taryn F Moy; Elliot K Fishman; Diane M Becker Journal: Circ Cardiovasc Imaging Date: 2014-02-27 Impact factor: 7.792
Authors: Antonia Trichopoulou; Nikos Yiannakouris; Christina Bamia; Vassiliki Benetou; Dimitrios Trichopoulos; Jose M Ordovas Journal: Arch Intern Med Date: 2008-04-28
Authors: Robert D Reid; Lisa A McDonnell; Dana L Riley; Amy E Mark; Lori Mosca; Louise Beaton; Sophia Papadakis; Chris M Blanchard; Heidi Mochari-Greenberger; Patricia O'Farrell; George A Wells; Monika E Slovinec D'Angelo; Andrew L Pipe Journal: CMAJ Date: 2013-11-18 Impact factor: 8.262
Authors: Choongki Kim; Hyuk-Jae Chang; Iksung Cho; Ji Min Sung; Donghoon Choi; Myung Ho Jeong; Yang Soo Jang Journal: Korean J Intern Med Date: 2013-08-14 Impact factor: 2.884
Authors: Audrey H H Merry; Jolanda M A Boer; Leo J Schouten; Edith J M Feskens; W M Monique Verschuren; Anton P M Gorgels; Piet A van den Brandt Journal: BMC Cardiovasc Disord Date: 2011-03-24 Impact factor: 2.298
Authors: Maren T Scheuner; Claude Messan Setodji; James S Pankow; Roger S Blumenthal; Emmett Keeler Journal: Genet Med Date: 2008-12 Impact factor: 8.822