Literature DB >> 12876195

Amplification of xenon NMR and MRI by remote detection.

Adam J Moulé1, Megan M Spence, Song-I Han, Juliette A Seeley, Kimberly L Pierce, Sunil Saxena, Alexander Pines.   

Abstract

A technique is proposed in which an NMR spectrum or MRI is encoded and stored as spin polarization and is then moved to a different physical location to be detected. Remote detection allows the separate optimization of the encoding and detection steps, permitting the independent choice of experimental conditions and excitation and detection methodologies. In the initial experimental demonstration of this technique, we show that taking dilute 129Xe from a porous sample placed inside a large encoding coil and concentrating it into a smaller detection coil can amplify NMR signal. In general, the study of NMR active molecules at low concentration that have low physical filling factor is facilitated by remote detection. In the second experimental demonstration, MRI information encoded in a very low-field magnet (4-7 mT) is transferred to a high-field magnet (4.2 T) to be detected under optimized conditions. Furthermore, remote detection allows the utilization of ultrasensitive optical or superconducting quantum interference device detection techniques, which broadens the horizon of NMR experimentation.

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Year:  2003        PMID: 12876195      PMCID: PMC170882          DOI: 10.1073/pnas.1133497100

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  9 in total

1.  Functionalized xenon as a biosensor.

Authors:  M M Spence; S M Rubin; I E Dimitrov; E J Ruiz; D E Wemmer; A Pines; S Q Yao; F Tian; P G Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-04       Impact factor: 11.205

2.  Low-field MRI of laser polarized noble gas.

Authors:  C H Tseng; G P Wong; V R Pomeroy; R W Mair; D P Hinton; D Hoffmann; R E Stoner; F W Hersman; D G Cory; R L Walsworth
Journal:  Phys Rev Lett       Date:  1998-10-26       Impact factor: 9.161

3.  Probing lung physiology with xenon polarization transfer contrast (XTC).

Authors:  K Ruppert; J R Brookeman; K D Hagspiel; J P Mugler
Journal:  Magn Reson Med       Date:  2000-09       Impact factor: 4.668

4.  Sensitivity enhancement in multiple-quantum NMR experiments with CPMG detection.

Authors:  Kwang Hun Lim; Tuan Nguyen; Tanya Mazur; David E Wemmer; Alexander Pines
Journal:  J Magn Reson       Date:  2002-07       Impact factor: 2.229

5.  Novel approaches to low-cost MRI.

Authors:  A Macovski; S Conolly
Journal:  Magn Reson Med       Date:  1993-08       Impact factor: 4.668

6.  Biological magnetic resonance imaging using laser-polarized 129Xe.

Authors:  M S Albert; G D Cates; B Driehuys; W Happer; B Saam; C S Springer; A Wishnia
Journal:  Nature       Date:  1994-07-21       Impact factor: 49.962

7.  Susceptibility artefacts in NMR imaging.

Authors:  K M Lüdeke; P Röschmann; R Tischler
Journal:  Magn Reson Imaging       Date:  1985       Impact factor: 2.546

8.  Mapping of metabolites in whole animals by 31P NMR using surface coils.

Authors:  J J Ackerman; T H Grove; G G Wong; D G Gadian; G K Radda
Journal:  Nature       Date:  1980-01-10       Impact factor: 49.962

9.  Xenon NMR: chemical shifts of a general anesthetic in common solvents, proteins, and membranes.

Authors:  K W Miller; N V Reo; A J Schoot Uiterkamp; D P Stengle; T R Stengle; K L Williamson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-08       Impact factor: 11.205

  9 in total
  18 in total

1.  Cell-compatible, integrin-targeted cryptophane-129Xe NMR biosensors.

Authors:  Garry K Seward; Yubin Bai; Najat S Khan; Ivan J Dmochowski
Journal:  Chem Sci       Date:  2011-06       Impact factor: 9.825

2.  Magnetic resonance imaging of oscillating electrical currents.

Authors:  Nicholas W Halpern-Manners; Vikram S Bajaj; Thomas Z Teisseyre; Alexander Pines
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-26       Impact factor: 11.205

3.  Microfluidic gas-flow profiling using remote-detection NMR.

Authors:  Christian Hilty; Erin E McDonnell; Josef Granwehr; Kimberly L Pierce; Song-I Han; Alexander Pines
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-07       Impact factor: 11.205

4.  Hyperpolarized krypton-83 as a contrast agent for magnetic resonance imaging.

Authors:  Galina E Pavlovskaya; Zackary I Cleveland; Karl F Stupic; Randall J Basaraba; Thomas Meersmann
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-12       Impact factor: 11.205

5.  Magnetic resonance imaging with an optical atomic magnetometer.

Authors:  Shoujun Xu; Valeriy V Yashchuk; Marcus H Donaldson; Simon M Rochester; Dmitry Budker; Alexander Pines
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-02       Impact factor: 11.205

6.  MRI without the magnet.

Authors:  Daniel Raftery
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-15       Impact factor: 11.205

7.  Zero-field remote detection of NMR with a microfabricated atomic magnetometer.

Authors:  M P Ledbetter; I M Savukov; D Budker; V Shah; S Knappe; J Kitching; D J Michalak; S Xu; A Pines
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-06       Impact factor: 11.205

8.  Remote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor.

Authors:  F Verpillat; M P Ledbetter; S Xu; D J Michalak; C Hilty; L-S Bouchard; S Antonijevic; D Budker; A Pines
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-11       Impact factor: 11.205

9.  Volume-selective magnetic resonance imaging using an adjustable, single-sided, portable sensor.

Authors:  Jeffrey L Paulsen; Louis S Bouchard; Dominic Graziani; Bernhard Blümich; Alexander Pines
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-17       Impact factor: 11.205

Review 10.  Sensitivity enhancement in solution NMR: emerging ideas and new frontiers.

Authors:  Jung Ho Lee; Yusuke Okuno; Silvia Cavagnero
Journal:  J Magn Reson       Date:  2014-04       Impact factor: 2.229

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