Literature DB >> 12871944

A new subfamily of the Nudix hydrolase superfamily active on 5-methyl-UTP (ribo-TTP) and UTP.

WenLian Xu1, JianYing Shen, Christopher A Dunn, Maurice J Bessman.   

Abstract

A new subfamily of the Nudix hydrolases, identified by conserved amino acids upstream and downstream of the Nudix box, has been characterized. The cloned, expressed, and purified orthologous enzymes have major activities on the non-canonical nucleoside triphosphate 5-methyl-UTP (ribo-TTP) and the canonical nucleotide UTP. In addition to their homologous signature sequences and their similar substrate specificities, the members of the subfamily are inhabitants of or are related to the bacterial rhizosphere. We propose the acronym and mnemonic, utp, for the gene designating this unique UTPase.

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Year:  2003        PMID： 12871944     DOI： 10.1074/jbc.M307639200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  9 in total

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Authors:  Andreas Tauch; Olaf Kaiser; Torsten Hain; Alexander Goesmann; Bernd Weisshaar; Andreas Albersmeier; Thomas Bekel; Nicole Bischoff; Iris Brune; Trinad Chakraborty; Jörn Kalinowski; Folker Meyer; Oliver Rupp; Susanne Schneiker; Prisca Viehoever; Alfred Pühler
Journal:  J Bacteriol       Date:  2005-07       Impact factor: 3.490

Review 2.  Genomics of Actinobacteria: tracing the evolutionary history of an ancient phylum.

Authors:  Marco Ventura; Carlos Canchaya; Andreas Tauch; Govind Chandra; Gerald F Fitzgerald; Keith F Chater; Douwe van Sinderen
Journal:  Microbiol Mol Biol Rev       Date:  2007-09       Impact factor: 11.056

3.  Identification of Nudix hydrolase family members with an antimutator role in Mycobacterium tuberculosis and Mycobacterium smegmatis.

Authors:  T Dos Vultos; J Blázquez; J Rauzier; I Matic; B Gicquel
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

4.  Gene ytkD of Bacillus subtilis encodes an atypical nucleoside triphosphatase member of the Nudix hydrolase superfamily.

Authors:  Wenlian Xu; Candice R Jones; Christopher A Dunn; Maurice J Bessman
Journal:  J Bacteriol       Date:  2004-12       Impact factor: 3.490

5.  Alternative splicing of the FGF antisense gene: differential subcellular localization in human tissues and esophageal adenocarcinoma.

Authors:  Shuo Cheng Zhang; Christie Barclay; Leigh Ann Alexander; Laurette Geldenhuys; Geoffrey A Porter; Alan G Casson; Paul R Murphy
Journal:  J Mol Med (Berl)       Date:  2007-06-14       Impact factor: 4.599

6.  Nudix hydrolases degrade protein-conjugated ADP-ribose.

Authors:  Casey M Daniels; Puchong Thirawatananond; Shao-En Ong; Sandra B Gabelli; Anthony K L Leung
Journal:  Sci Rep       Date:  2015-12-16       Impact factor: 4.379

7.  Characterization of a nudix hydrolase from Deinococcus radiodurans with a marked specificity for (deoxy)ribonucleoside 5'-diphosphates.

Authors:  David I Fisher; Jared L Cartwright; Hideyoshi Harashima; Hiroyuki Kamiya; Alexander G McLennan
Journal:  BMC Biochem       Date:  2004-05-17       Impact factor: 4.059

8.  Biochemical and structural studies of conserved Maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides.

Authors:  Anatoli Tchigvintsev; Dmitri Tchigvintsev; Robert Flick; Ana Popovic; Aiping Dong; Xiaohui Xu; Greg Brown; Wenyun Lu; Hong Wu; Hong Cui; Ludmila Dombrowski; Jeong Chan Joo; Natalia Beloglazova; Jinrong Min; Alexei Savchenko; Amy A Caudy; Joshua D Rabinowitz; Alexey G Murzin; Alexander F Yakunin
Journal:  Chem Biol       Date:  2013-10-24

9.  Substrate specificity characterization for eight putative nudix hydrolases. Evaluation of criteria for substrate identification within the Nudix family.

Authors:  Vi N Nguyen; Annsea Park; Anting Xu; John R Srouji; Steven E Brenner; Jack F Kirsch
Journal:  Proteins       Date:  2016-10-01
  9 in total

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