Literature DB >> 12871124

The mitochondrial voltage-dependent anion channel (VDAC) as a therapeutic target for initiating cell death.

David J Granville1, Roberta A Gottlieb.   

Abstract

Voltage-dependent anion channels (VDAC) are major constituents of the outer mitochondrial membrane. Over the past few years, several hypotheses and mechanisms have been forwarded for and against a role for VDAC in outer mitochondrial membrane permeability and the subsequent release of apoptosis promoting factors. The current review outlines current knowledge related to the role of VDAC in the regulation of cell death and speculates on possible therapeutic applications through VDAC modulation.

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Year:  2003        PMID： 12871124     DOI： 10.2174/0929867033457214

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  19 in total

1.  Structure-based analysis of VDAC1 protein: defining oligomer contact sites.

Authors:  Shay Geula; Hammad Naveed; Jie Liang; Varda Shoshan-Barmatz
Journal:  J Biol Chem       Date:  2011-11-23       Impact factor: 5.157

Review 2.  Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis.

Authors:  Lee J Martin
Journal:  IDrugs       Date:  2010-08

Review 3.  Structure of the voltage dependent anion channel: state of the art.

Authors:  Vito De Pinto; Simona Reina; Francesca Guarino; Angela Messina
Journal:  J Bioenerg Biomembr       Date:  2008-06       Impact factor: 2.945

Review 4.  Uncovering the role of VDAC in the regulation of cell life and death.

Authors:  Varda Shoshan-Barmatz; Nurit Keinan; Hilal Zaid
Journal:  J Bioenerg Biomembr       Date:  2008-06       Impact factor: 2.945

5.  MAVS regulates apoptotic cell death by decreasing K48-linked ubiquitination of voltage-dependent anion channel 1.

Authors:  Kai Guan; Zirui Zheng; Ting Song; Xiang He; Changzhi Xu; Yanhong Zhang; Shengli Ma; Ying Wang; Quanbin Xu; Ye Cao; Jia Li; Xiaoli Yang; Xiaoxing Ge; Congwen Wei; Hui Zhong
Journal:  Mol Cell Biol       Date:  2013-06-10       Impact factor: 4.272

Review 6.  Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria.

Authors:  S P Mathupala; Y H Ko; P L Pedersen
Journal:  Oncogene       Date:  2006-08-07       Impact factor: 9.867

7.  Solution NMR spectroscopic characterization of human VDAC-2 in detergent micelles and lipid bilayer nanodiscs.

Authors:  Tsyr-Yan Yu; Thomas Raschle; Sebastian Hiller; Gerhard Wagner
Journal:  Biochim Biophys Acta       Date:  2011-11-15

8.  The regulation of apoptosis by the downstream regulatory element antagonist modulator/potassium channel interacting protein 3 (DREAM/KChIP3) through interactions with hexokinase I.

Authors:  Theodore A Craig; Pradeep L Ramachandran; H Robert Bergen; Jewel L Podratz; Anthony J Windebank; Rajiv Kumar
Journal:  Biochem Biophys Res Commun       Date:  2013-03-21       Impact factor: 3.575

Review 9.  Inhibition of mitochondrial membrane permeability as a putative pharmacological target for cardioprotection.

Authors:  D Morin; R Assaly; S Paradis; A Berdeaux
Journal:  Curr Med Chem       Date:  2009       Impact factor: 4.530

Review 10.  Nanotechnology inspired tools for mitochondrial dysfunction related diseases.

Authors:  Ru Wen; Bhabatosh Banik; Rakesh K Pathak; Anil Kumar; Nagesh Kolishetti; Shanta Dhar
Journal:  Adv Drug Deliv Rev       Date:  2016-01-09       Impact factor: 15.470
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