Literature DB >> 12856834

1-Methylnicotinamide: a potent anti-inflammatory agent of vitamin origin.

Jerzy Gebicki1, Anna Sysa-Jedrzejowska, Jan Adamus, Anna Woźniacka, Małgorzata Rybak, Jacek Zielonka.   

Abstract

It has been found that 1-methylnicotinamide (MNA+), a metabolite of nicotinamide, possesses significant anti-inflammatory properties. MNA+ is chemically stable, non-toxic and well tolerated. MNA+ can be used to treat wide variety of diseases and disorders and the use of this compound provides certain advantages over the use of nicotinamide.

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Year:  2003        PMID： 12856834

Source DB:  PubMed          Journal:  Pol J Pharmacol        ISSN： 1230-6002


  25 in total

1.  NMR-based metabolomics of urine for the atherosclerotic mouse model using apolipoprotein-E deficient mice.

Authors:  Gregory C Leo; Andrew L Darrow
Journal:  Magn Reson Chem       Date:  2009-12       Impact factor: 2.447

2.  N-Methyl-2-pyridone-5-carboxamide is 1-methylnicotinamide metabolite of low cyclooxygenase-dependent vasodilating activity.

Authors:  Tomasz Przygodzki; Bartlomiej Grobelski; Piotr Kazmierczak; Cezary Watala
Journal:  J Physiol Biochem       Date:  2012-01-13       Impact factor: 4.158

3.  Effects of N1-methylnicotinamide on oxidative and glycooxidative stress markers in rats with streptozotocin-induced diabetes mellitus.

Authors:  Zuzana Országhová; Ol'ga Uličná; Anna Liptáková; Ingrid Zitňanová; Jana Muchová; Cezary Watala; Zdeňka Duračková
Journal:  Redox Rep       Date:  2012       Impact factor: 4.412

4.  Diaqua-bis(5-bromo-2-hydroxy-benzoato)bis-(N-methyl-nicotinamide)zinc(II).

Authors:  Zuzana Bujdošová; Juraj Kuchár; Katarína Györyová
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-13

5.  Using urine metabolomics to understand the pathogenesis of infant respiratory syncytial virus (RSV) infection and its role in childhood wheezing.

Authors:  Kedir N Turi; Lindsey Romick-Rosendale; Tebeb Gebretsadik; Miki Watanabe; Steven Brunwasser; Larry J Anderson; Martin L Moore; Emma K Larkin; Ray Stokes Peebles; Tina V Hartert
Journal:  Metabolomics       Date:  2018-10-01       Impact factor: 4.290

6.  Antiatherosclerotic Effects of 1-Methylnicotinamide in Apolipoprotein E/Low-Density Lipoprotein Receptor-Deficient Mice: A Comparison with Nicotinic Acid.

Authors:  Lukasz Mateuszuk; Agnieszka Jasztal; Edyta Maslak; Marlena Gasior-Glogowska; Malgorzata Baranska; Barbara Sitek; Renata Kostogrys; Agnieszka Zakrzewska; Agnieszka Kij; Maria Walczak; Stefan Chlopicki
Journal:  J Pharmacol Exp Ther       Date:  2015-12-02       Impact factor: 4.030

7.  1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway.

Authors:  S Chlopicki; J Swies; A Mogielnicki; W Buczko; M Bartus; M Lomnicka; J Adamus; J Gebicki
Journal:  Br J Pharmacol       Date:  2007-07-16       Impact factor: 8.739

8.  Higher maternal serum concentrations of nicotinamide and related metabolites in late pregnancy are associated with a lower risk of offspring atopic eczema at age 12 months.

Authors:  S El-Heis; S R Crozier; S M Robinson; N C Harvey; C Cooper; H M Inskip; K M Godfrey
Journal:  Clin Exp Allergy       Date:  2016-09-15       Impact factor: 5.018

9.  1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages.

Authors:  Rafał Biedroń; Marta Ciszek; Marianna Tokarczyk; Małgorzata Bobek; Maria Kurnyta; Ewa M Słominska; Ryszard T Smoleński; Janusz Marcinkiewicz
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2008-03-31       Impact factor: 4.291

10.  Disparate Metabolomic Responses to Fructose Consumption between Different Mouse Strains and the Role of Gut Microbiota.

Authors:  In Sook Ahn; Justin Yoon; Graciel Diamante; Peter Cohn; Cholsoon Jang; Xia Yang
Journal:  Metabolites       Date:  2021-05-26
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