OBJECTIVE: To examine whether CO poisoning induces a significant increase in plasma lactate concentration. DESIGN AND SETTING: Prospective observational clinical study in the emergency department and intensive care unit in a university-affiliated teaching hospital. PATIENTS: 146 pure CO poisonings resulting from dysfunction of gas cookers or water heaters. MEASUREMENTS AND RESULTS: Patients were classified into four neurological impairment groups: 37% were severely, 8% moderately, and 45% mildly intoxicated, while 1% were asymptomatic. We found only very mild increases in plasma lactate concentration (median 2.30 mmol/l) which, however, was significantly correlated with the severity of neurological impairment and blood CO concentration (1.41 mmol/l, Spearman's test r=0.3). CONCLUSIONS: Plasma lactate is mildly elevated in pure CO-exposed patients. This mild increase and the extensive overlap between the groups of neurological impairment severity do not suggest the usefulness of systematic plasma lactate measurement in pure CO poisoning.
OBJECTIVE: To examine whether CO poisoning induces a significant increase in plasma lactate concentration. DESIGN AND SETTING: Prospective observational clinical study in the emergency department and intensive care unit in a university-affiliated teaching hospital. PATIENTS: 146 pure CO poisonings resulting from dysfunction of gas cookers or water heaters. MEASUREMENTS AND RESULTS:Patients were classified into four neurological impairment groups: 37% were severely, 8% moderately, and 45% mildly intoxicated, while 1% were asymptomatic. We found only very mild increases in plasma lactate concentration (median 2.30 mmol/l) which, however, was significantly correlated with the severity of neurological impairment and blood CO concentration (1.41 mmol/l, Spearman's test r=0.3). CONCLUSIONS: Plasma lactate is mildly elevated in pure CO-exposed patients. This mild increase and the extensive overlap between the groups of neurological impairment severity do not suggest the usefulness of systematic plasma lactate measurement in pure CO poisoning.
Authors: Lindell K Weaver; Ramona O Hopkins; Karen J Chan; Susan Churchill; C Gregory Elliott; Terry P Clemmer; James F Orme; Frank O Thomas; Alan H Morris Journal: N Engl J Med Date: 2002-10-03 Impact factor: 91.245
Authors: F J Baud; P Barriot; V Toffis; B Riou; E Vicaut; Y Lecarpentier; R Bourdon; A Astier; C Bismuth Journal: N Engl J Med Date: 1991-12-19 Impact factor: 91.245
Authors: Frédéric J Baud; Stephen W Borron; Bruno Mégarbane; Hervé Trout; Frédéric Lapostolle; Eric Vicaut; Marcel Debray; Chantal Bismuth Journal: Crit Care Med Date: 2002-09 Impact factor: 7.598