BACKGROUND: Although active smoking acutely increases arterial stiffness, the association between arterial stiffness and chronic exposure to environmental tobacco smoke (ETS) has not been evaluated. We used baseline data from the Vitamin E Atherosclerosis Prevention Study to evaluate the association between ETS exposure and arterial stiffness among 227 healthy adult nonsmokers. METHODS: B-mode ultrasonograms of the common carotid artery were used to compute the carotid arterial wall stiffness index beta. Beta was compared by the number of sources and daily hours of ETS exposure. RESULTS: The carotid stiffness index beta was positively associated with age, body mass index (BMI), fasting glucose, and common carotid artery intima-media thickness (IMT). In the total sample, beta was not related to the number of ETS exposure sources. The carotid stiffness index beta increased with number of sources and daily hours of ETS in subjects with BMI > or =27.1 kg/m2 and IMT > or =0.707 mm. The association was not apparent in subjects with lower BMI or IMT (for number of ETS sources, interaction P values=0.006 and 0.01, respectively). For number of ETS sources, but not hours of exposure, positive associations were apparent among females (but not males) and among subjects > or =55 years old (but not younger subjects). CONCLUSIONS: These data indicate that arterial stiffness is adversely associated with ETS in a dose-dependent manner among individuals with higher BMI and greater carotid artery IMT.
BACKGROUND: Although active smoking acutely increases arterial stiffness, the association between arterial stiffness and chronic exposure to environmental tobacco smoke (ETS) has not been evaluated. We used baseline data from the Vitamin EAtherosclerosis Prevention Study to evaluate the association between ETS exposure and arterial stiffness among 227 healthy adult nonsmokers. METHODS: B-mode ultrasonograms of the common carotid artery were used to compute the carotid arterial wall stiffness index beta. Beta was compared by the number of sources and daily hours of ETS exposure. RESULTS: The carotid stiffness index beta was positively associated with age, body mass index (BMI), fasting glucose, and common carotid artery intima-media thickness (IMT). In the total sample, beta was not related to the number of ETS exposure sources. The carotid stiffness index beta increased with number of sources and daily hours of ETS in subjects with BMI > or =27.1 kg/m2 and IMT > or =0.707 mm. The association was not apparent in subjects with lower BMI or IMT (for number of ETS sources, interaction P values=0.006 and 0.01, respectively). For number of ETS sources, but not hours of exposure, positive associations were apparent among females (but not males) and among subjects > or =55 years old (but not younger subjects). CONCLUSIONS: These data indicate that arterial stiffness is adversely associated with ETS in a dose-dependent manner among individuals with higher BMI and greater carotid artery IMT.
Authors: Carrie V Breton; Fen Yin; Xinhui Wang; Ed Avol; Frank D Gilliland; Jesus A Araujo Journal: Atherosclerosis Date: 2013-11-15 Impact factor: 5.162
Authors: Geetha Raghuveer; David A White; Laura L Hayman; Jessica G Woo; Juan Villafane; David Celermajer; Kenneth D Ward; Sarah D de Ferranti; Justin Zachariah Journal: Circulation Date: 2016-09-12 Impact factor: 29.690
Authors: Marie S O'Neill; Ana V Diez-Roux; Amy H Auchincloss; Mingwu Shen; João A Lima; Joseph F Polak; R Graham Barr; Joel Kaufman; David R Jacobs Journal: Environ Health Perspect Date: 2011-01-18 Impact factor: 9.031
Authors: Frank Peinemann; Susanne Moebus; Nico Dragano; Stefan Möhlenkamp; Nils Lehmann; Hajo Zeeb; Raimund Erbel; Karl-Heinz Jöckel; Barbara Hoffmann Journal: Environ Health Perspect Date: 2011-07-08 Impact factor: 9.031
Authors: Nino Künzli; Michael Jerrett; Wendy J Mack; Bernardo Beckerman; Laurie LaBree; Frank Gilliland; Duncan Thomas; John Peters; Howard N Hodis Journal: Environ Health Perspect Date: 2005-02 Impact factor: 9.031