Literature DB >> 12852975

1,2,4-Triazolo mercapto and aminonitriles as potent antifungal agents.

Xavier Collin1, Armelle Sauleau, Joël Coulon.   

Abstract

A series of 3-mercapto-1,2,4-triazoles mono or disubstituted at 2-, 3- or 4-positions were synthesized and evaluated as antifungal agents. Many of these derivatives exhibit high activity against Candida albicans and Candida tropicalis.

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Year:  2003        PMID： 12852975     DOI： 10.1016/s0960-894x(03)00378-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  15 in total

1.  Novel triazole alcohol antifungals derived from fluconazole: design, synthesis, and biological activity.

Authors:  Seyedeh Mahdieh Hashemi; Hamid Badali; Mohammad Ali Faramarzi; Nasrin Samadi; Mohammad Hosein Afsarian; Hamid Irannejad; Saeed Emami
Journal:  Mol Divers       Date:  2014-09-03       Impact factor: 2.943

2.  Molecular docking studies, biological evaluation and synthesis of novel 3-mercapto-1,2,4-triazole derivatives.

Authors:  Javad Ghanaat; Mohammad A Khalilzadeh; Daryoush Zareyee
Journal:  Mol Divers       Date:  2020-02-17       Impact factor: 2.943

3.  4-Amino-3,5-dimethyl-4H1-,2,4-triazole-water (2/3).

Authors:  Lin Cheng; Ya-Wen Zhang; Yan-Yan Sun; Gang Xu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-09-06

4.  1-Benzoyl-methyl-3-(2-thienylmeth-yl)-4-(2-thienylmethyl-eneamino)-1H-1,2,4-triazol-5(4H)-one.

Authors:  Hasan Tanak; Metin Yavuz; Zeliha Lagap; Orhan Büyükgüngör
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-01-09

5.  2-[4-(4-Methoxy-phen-yl)-5-(2-pyrid-yl)-4H-1,2,4-triazol-3-yl]phenol.

Authors:  Mei-An Zhu; Zhao-Di Liu; Shu-Ping Zhang; Ying Wei; Si-Chang Shao
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-06-27

6.  4-Ethyl-3-(2-thienylmeth-yl)-Δ-1,2,4-triazoline-5-thione.

Authors:  Monika Wujec; Liliana Mazur; Zofia Rzączyńska
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-01-10

7.  A second ortho-rhom-bic polymorph of 3,5-diphenyl-4H-1,2,4-triazol-4-amine.

Authors:  Ya-Wen Zhang; Jian-Quan Wang; Lin Cheng
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-08-29

8.  Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIs.

Authors:  Jingde Wu; Xinyong Liu; Xianchao Cheng; Yuan Cao; Defeng Wang; Zhong Li; Wenfang Xu; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq
Journal:  Molecules       Date:  2007-08-22       Impact factor: 4.411

9.  Novel ferrocenyl derivatives exert anti-cancer effect in human lung cancer cells in vitro via inducing G1-phase arrest and senescence.

Authors:  Ying Li; Han-lin Ma; Lei Han; Wei-yong Liu; Bao-xiang Zhao; Shang-li Zhang; Jun-ying Miao
Journal:  Acta Pharmacol Sin       Date:  2013-05-06       Impact factor: 6.150

10.  Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction.

Authors:  Tummala R K Reddy; Chan Li; Peter M Fischer; Lodewijk V Dekker
Journal:  ChemMedChem       Date:  2012-05-29       Impact factor: 3.466
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