Literature DB >> 12851556

Enlarged vestibular aqueduct syndrome in the pediatric population.

Colm Madden1, Mark Halsted, Corning Benton, John Greinwald, Daniel Choo.   

Abstract

OBJECTIVE: To correlate clinical and audiometric findings with the radiologic appearance in patients with enlarged vestibular aqueduct.DESIGN A retrospective review of data from enlarged vestibular aqueduct patients identified in a pediatric hearing-impaired database of 1,200 patients. SETTING A tertiary care pediatric referral center. PATIENTS: Subjects were included for study with a radiographic diagnosis of enlarged vestibular aqueducts in at least one ear by a pediatric neuroradiologist. MAIN OUTCOME MEASURES: Audiometric evaluations and radiographic temporal bone measurements.
RESULTS: Seventy-seven patients were identified with an enlarged vestibular aqueduct with a male-to-female ratio of 1:1.5. Patients were followed for a mean of 34 months (range, 0-179 months). Hearing loss was bilateral in 87% of cases. Vestibular symptoms were present in only three (4%) of the patients. Three patients (4%) suffered a sudden decrease in hearing after mild head trauma. Borderline enlargement of the vestibular aqueduct was associated with varying degrees of sensorineural hearing loss. Ninety-seven percent (64 of 66) of ears in control subjects with no sensorineural hearing loss had normal vestibular aqueduct measurements at the midpoint and operculum. Overall, the audiogram remained stable in 51% of ears, fluctuated in 28%, and progressively worsened in 21%. Measurements of the vestibular aqueduct at the midpoint and the operculum did not correlate with the audiometric threshold or the audiogram configuration. However, mean vestibular aqueduct size at the operculum was significantly larger in those with a progressive loss when compared with those with a fluctuating or stable hearing outcome.
CONCLUSIONS: Overall, audiometric thresholds remained generally stable, with sudden deterioration of hearing after head trauma seen in only three male patients. Progression of hearing loss after head trauma was not a significant finding in our patient population. Vestibular aqueduct opercular size alone showed a direct correlation with the audiometric outcome. Borderline enlarged vestibular aqueduct measurements appear to be associated with sensorineural hearing loss.

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Mesh:

Year:  2003        PMID: 12851556     DOI: 10.1097/00129492-200307000-00016

Source DB:  PubMed          Journal:  Otol Neurotol        ISSN: 1531-7129            Impact factor:   2.311


  16 in total

1.  Computed tomography of the inner ear: size of anatomical structures in the normal temporal bone and in the temporal bone of patients with Menière's disease.

Authors:  Gabriele A Krombach; Martin van den Boom; Ercole Di Martino; Thomas Schmitz-Rode; Martin Westhofen; Andreas Prescher; Rolf W Günther; Joachim E Wildberger
Journal:  Eur Radiol       Date:  2005-04-12       Impact factor: 5.315

2.  [Large endolymphatic duct and sac syndrome : part 2: clinical manifestations].

Authors:  S Bartel-Friedrich; M Fuchs; B Amaya; C Rasinski; S Meuret; S Kösling
Journal:  HNO       Date:  2008-02       Impact factor: 1.284

3.  [Large endolymphatic duct and sac syndrome (LEDS) : part I: analysis of imaging findings].

Authors:  S Bartel-Friedrich; B Amaya; C Rasinski; M Fuchs; S Kösling
Journal:  HNO       Date:  2008-02       Impact factor: 1.284

4.  Towards an etiologic diagnosis: assessing the patient with hearing loss.

Authors:  J Jerry; John S Oghalai
Journal:  Adv Otorhinolaryngol       Date:  2011-02-24

5.  Progression of Unilateral Hearing Loss in Children With and Without Ipsilateral Cochlear Nerve Canal Stenosis: A Hazard Analysis.

Authors:  Patricia L Purcell; Justin R Shinn; Scott S Coggeshall; Grace Phillips; Angelisa Paladin; Kathleen C Y Sie; David L Horn
Journal:  Otol Neurotol       Date:  2017-07       Impact factor: 2.311

6.  SLC26A4 genotype, but not cochlear radiologic structure, is correlated with hearing loss in ears with an enlarged vestibular aqueduct.

Authors:  Kelly A King; Byung Yoon Choi; Christopher Zalewski; Anne C Madeo; Ani Manichaikul; Shannon P Pryor; Anne Ferruggiaro; David Eisenman; H Jeffrey Kim; John Niparko; James Thomsen; John A Butman; Andrew J Griffith; Carmen C Brewer
Journal:  Laryngoscope       Date:  2010-02       Impact factor: 3.325

7.  Vestibular Dysfunction in Patients with Enlarged Vestibular Aqueduct.

Authors:  Chris K Zalewski; Wade W Chien; Kelly A King; Julie A Muskett; Rachel E Baron; John A Butman; Andrew J Griffith; Carmen C Brewer
Journal:  Otolaryngol Head Neck Surg       Date:  2015-05-12       Impact factor: 3.497

8.  SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct.

Authors:  Taku Ito; Julie Muskett; Parna Chattaraj; Byung Yoon Choi; Kyu Yup Lee; Christopher K Zalewski; Kelly A King; Xiangming Li; Philine Wangemann; Thomas Shawker; Carmen C Brewer; Seth L Alper; Andrew J Griffith
Journal:  World J Otorhinolaryngol       Date:  2013-05-28

9.  Long-term follow-up in patients with Pendred syndrome: vestibular, auditory and other phenotypes.

Authors:  Makoto Sugiura; Eisuke Sato; Tsutomu Nakashima; Junko Sugiura; Atsushi Furuhashi; Takahiko Yoshino; Atsuo Nakayama; Naoyoshi Mori; Hideki Murakami; Shinji Naganawa
Journal:  Eur Arch Otorhinolaryngol       Date:  2005-03-04       Impact factor: 2.503

10.  When is the vestibular aqueduct enlarged? A statistical analysis of the normative distribution of vestibular aqueduct size.

Authors:  S Vijayasekaran; M J Halsted; M Boston; J Meinzen-Derr; D M E Bardo; J Greinwald; C Benton
Journal:  AJNR Am J Neuroradiol       Date:  2007 Jun-Jul       Impact factor: 3.825

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