| Literature DB >> 12846478 |
Yoshio Yamamoto1, Minako Fujimura, Toshiho Nishita, Kazutoshi Nishijima, Yasuro Atoji, Yoshitaka Suzuki.
Abstract
The rat carotid body was immunohistochemically stained for carbonic anhydrase I, II and III (CA-I, CA-II and CA-III). Immunoreactivity for CA-I was distributed in type I cells, type II cells and nerve bundles. Smooth muscle cells and endothelial cells of blood vessels were also strongly stained for CA-I. CA-II immunoreactivity was distinctly positive in type I cells and nerve bundles. Vascular smooth muscle cells were weakly positive, and type II cells were negative for CA-II. CA-III immunoreactivity was identified in type I cells and vascular smooth muscle cells. Our results suggest that carbonic anhydrase isozymes in type I cells play an important role in chemoreception for hypercapnia. Immunoreactivities for CA-I and CA-II in the nerve fibres may participate in the synergic action of carotid sinus nerve between hypoxic and hypercapnic stimuli.Entities:
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Year: 2003 PMID： 12846478 PMCID： PMC1571107 DOI： 10.1046/j.1469-7580.2003.00191.x
Source DB: PubMed Journal: J Anat ISSN： 0021-8782 Impact factor: 2.610