Literature DB >> 12231257

TASK-1, TASK-2, TASK-3 and TRAAK immunoreactivities in the rat carotid body.

Yoshio Yamamoto1, Wolfgang Kummer, Yasuro Atoji, Yoshitaka Suzuki.   

Abstract

In the present study, we investigated the immunohistochemical localization of two-pore K(+)-channels TASK-1, TASK-2, TASK-3 and TRAAK in the rat carotid body. Type I cells were positive for TASK-1, TASK-2, TASK-3 and TRAAK. Intrinsic nerve cell bodies were also strongly positive for TASK-1, TASK-2 and TRAAK, but negative for TASK-3. In addition, some type II cells, Schwann cells in the nerve bundles and fibroblast between type I cell clusters were also immunostained for TASK-1. Smooth muscle cells of the carotid body artery were intensely positive for TASK-3. Our results indicate that TASK-1 immunoreactivity was ubiquitously distributed in many cell types and immunoreactivities for TASK-2, TASK-3 and TRAAK were cell type specific distribution patterns in the rat carotid body.

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Year:  2002        PMID： 12231257     DOI： 10.1016/s0006-8993(02)03181-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  17 in total

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