Literature DB >> 1650278

The presence of CO2/HCO3- is essential for hypoxic chemotransduction in the in vivo perfused carotid body.

M Shirahata1, R S Fitzgerald.   

Abstract

Carotid chemoreceptor activity was increased by the perfusion of the carotid body in vivo with hypoxic HEPES-buffered solution (HBS) containing CO2/HCO3- (HBA+), but not with hypoxic HBS without CO2/HCO3- (HBS-). When the perfusate was switched to hypoxic HBS+ during hypoxic HBS-perfusions, chemoreceptor activity increased immediately. Thus, CO2/HCO3- played a critical role in the hypoxic chemotransduction of the in vivo perfused carotid body.

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Year:  1991        PMID： 1650278     DOI： 10.1016/0006-8993(91)91301-g

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

1.  Immunohistochemical localization of carbonic anhydrase isozymes in the rat carotid body.

Authors:  Yoshio Yamamoto; Minako Fujimura; Toshiho Nishita; Kazutoshi Nishijima; Yasuro Atoji; Yoshitaka Suzuki
Journal:  J Anat       Date:  2003-06       Impact factor: 2.610

Review 2.  Peripheral chemoreceptors: function and plasticity of the carotid body.

Authors:  Prem Kumar; Nanduri R Prabhakar
Journal:  Compr Physiol       Date:  2012-01       Impact factor: 9.090

3.  Modulation of glomus cell membrane currents of intact rat carotid body.

Authors:  D F Donnelly
Journal:  J Physiol       Date:  1995-12-15       Impact factor: 5.182

4.  Synapse formation and hypoxic signalling in co-cultures of rat petrosal neurones and carotid body type 1 cells.

Authors:  H Zhong; M Zhang; C A Nurse
Journal:  J Physiol       Date:  1997-09-15       Impact factor: 5.182

Review 5.  Hypoxia. 4. Hypoxia and ion channel function.

Authors:  Larissa A Shimoda; Jan Polak
Journal:  Am J Physiol Cell Physiol       Date:  2010-12-22       Impact factor: 4.249

6.  Effects of hypoxia and dithionite on catecholamine release from isolated type I cells of the rat carotid body.

Authors:  E Carpenter; C J Hatton; C Peers
Journal:  J Physiol       Date:  2000-03-15       Impact factor: 5.182

7.  Developmental changes in hypoxia-induced catecholamine release from rat carotid body, in vitro.

Authors:  D F Donnelly; T P Doyle
Journal:  J Physiol       Date:  1994-03-01       Impact factor: 5.182

8.  Effects of modulators of AMP-activated protein kinase on TASK-1/3 and intracellular Ca(2+) concentration in rat carotid body glomus cells.

Authors:  Donghee Kim; Dawon Kang; Elizabeth A Martin; Insook Kim; John L Carroll
Journal:  Respir Physiol Neurobiol       Date:  2014-02-13       Impact factor: 1.931

Review 9.  Carotid body chemoreceptors: physiology, pathology, and implications for health and disease.

Authors:  Rodrigo Iturriaga; Julio Alcayaga; Mark W Chapleau; Virend K Somers
Journal:  Physiol Rev       Date:  2021-02-11       Impact factor: 46.500
  9 in total

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