Literature DB >> 15793137

Molecular mechanisms by which rRNA mutations confer resistance to clindamycin.

Jacob Poehlsgaard1, Peter Pfister, Erik C Böttger, Stephen Douthwaite.   

Abstract

The mechanisms by which rRNA mutations confer clindamycin resistance were examined in Mycobacterium smegmatis strains containing homogeneous populations of ribosomes with base substitutions at nucleotides A2058 and A2059. Computer graphic predictions based on structural studies correlate with the resistance phenotypes for six of seven strains with unique rRNA mutations.

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Year:  2005        PMID： 15793137      PMCID： PMC1068640          DOI： 10.1128/AAC.49.4.1553-1555.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

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  7 in total

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