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Literature DB >> 128375

Specific and nonspecific channels leading to proteolysis in antibody preparations.

Abstract

Current ways of fractionating immune sera give rise in the guinea-pig species to an active plasmin that contaminates antibody preparations. The enzyme appears as a free molecule separable from the immunoglobulin. In contrast, when a purified antibody has been obtained through the immunoabsorption process, plasmin activated during the contact between antibody and polymer binds firmly to the immunoglobulin. This phenomenon occurs separately and indistinctly with IgG1 and IgG2. Moreover, the alternate pathway of complement activation could be a tributary to the plasmin system.

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Year: 1975 PMID： 128375 PMCID： PMC2072740

Source DB: PubMed Journal: Br J Exp Pathol ISSN： 0007-1021

18 in total

10. Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and description of an anaphylatoxin inactivator of human serum.

Authors: V A Bokisch; H J Müller-Eberhard; C G Cochrane
Journal: J Exp Med Date: 1969-05-01 Impact factor: 14.307

1 in total

1. Advantages and limitations of staphylococcal protein A-Sepharose for isolating soluble immune complexes from goat, rabbit and human sera.

Authors: M A Reisberg; R D Rossen
Journal: Clin Exp Immunol Date: 1981-11 Impact factor: 4.330

1 in total

Specific and nonspecific channels leading to proteolysis in antibody preparations.

1. Biochemical mechanism of the allergic reaction.

2. The fibrin plate method for estimating fibrinolytic activity.

3. Interactions between human C5, C6, and C7 and their functional significance in complement-dependent cytolysis.

4. The cross-linking of proteins with glutaraldehyde and its use for the preparation of immunoadsorbents.

5. Dual pathways of complement interaction with guinea pig immunoglobulins.

6. Plasminogen: purification from human plasma by affinity chromatography.

7. Two complement interaction sites in guinea pig immunoglobulins.

8. Studies on the activation of serum protease by an antigen-antibody system.

9. The inactivation of complement and its components by plasmin.

10. Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and description of an anaphylatoxin inactivator of human serum.

1. Advantages and limitations of staphylococcal protein A-Sepharose for isolating soluble immune complexes from goat, rabbit and human sera.