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Literature DB >> 13052811

Studies on the activation of serum protease by an antigen-antibody system.

Abstract

The results obtained in this study indicate that serum protease is not activated by either a rabbit or guinea pig antiovalbumin-ovalbumin system, in vitro. A precipitin reaction occurring in the presence of a serum protease precursor of three species (human, rabbit, and guinea pig) failed to activate the protease precursor. Furthermore, particulate material as preformed precipitates could not be shown to activate the protease of either human or rabbit serum or their euglobulin fractions. The material presented seems to be further evidence against the postulated role of serum protease in immunologic systems.

Entities: Species

Keywords: ALBUMIN; FIBRINOLYSIN

Mesh：

Substances：

Year: 1953 PMID： 13052811 PMCID： PMC2136266 DOI： 10.1084/jem.97.3.439

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

25 in total

4. Variations in the proteolytic and the antiproteolytic reactions of serum: effect of disease, trauma, x-ray, anaphylactic shock, ACTH, and cortisone.

Authors: E E CLIFFTON
Journal: J Lab Clin Med Date: 1952-01

9. Studies on the fibrinolysin-antifibrinolysin system in serum. I. Action of the anterior pituitary, adrenal cortex, and spleen.

Authors: G UNGAR; E DAMGAARD
Journal: J Exp Med Date: 1951-01 Impact factor: 14.307

Studies on the activation of serum protease by an antigen-antibody system.

1. STUDIES ON BLOOD COAGULATION: A PROTEOLYTIC ENZYME PREPARED FROM CALCIUM AND PLATELET FREE NORMAL HUMAN BLOOD PLASMA.

2. Protease inhibitors, assay and nature of serum antiprotease.

3. Inhibition of the growth of viruses in the chick embryo by aromatic diamidines.

4. Variations in the proteolytic and the antiproteolytic reactions of serum: effect of disease, trauma, x-ray, anaphylactic shock, ACTH, and cortisone.

5. A proteolytic enzyme system of the blood. III. Activation of dog serum profibrinolysin by staphylokinase.

6. Variations in proteolytic activity of serum of animals including man.

7. Partial purification and properties of a proteolytic enzyme of human serum.

8. Variations in proteolytic activity of serum of animals including man.

9. Studies on the fibrinolysin-antifibrinolysin system in serum. I. Action of the anterior pituitary, adrenal cortex, and spleen.

10. Observations on the release of serum fibrinolysin by specific antigen, peptone, and certain polysaccharides.

1. Specific and nonspecific channels leading to proteolysis in antibody preparations.

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4. The release of histamine and 5-hydroxytryptamine (serotonin) from platelets by antigen-antibody reactions (in vitro).

5. Activation of profibrinolysin by antigen-antibody reaction and by anaphylactoid agents; its relation to complement.