Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Applications of NMR to structure-based drug design in structural genomics.

Literature DB >> 12836668

Applications of NMR to structure-based drug design in structural genomics.

Abstract

Structural genomics is poised to have a tremendous impact on traditional structure-based drug design programs. As a result, there is a growing need to obtain rapid structural information in a reliable form that is amenable to rational drug design. In this manner, NMR has been expanding and evolving its role in aiding the design process. A variety of NMR methodologies that cover a range of inherent resolution are described in the context of structure-based drug design in the era of structural genomics.

Mesh：

Substances：

Year: 2002 PMID： 12836668 DOI： 10.1023/a:1020445506369

Source DB: PubMed Journal: J Struct Funct Genomics ISSN： 1345-711X

55 in total

Review 1. NMR techniques for characterization of ligand binding: utility for lead generation and optimization in drug discovery.

Authors: J M Moore
Journal: Biopolymers Date: 1999 Impact factor: 2.505

Review 2. Automated analysis of NMR assignments and structures for proteins.

Authors: H N Moseley; G T Montelione
Journal: Curr Opin Struct Biol Date: 1999-10 Impact factor: 6.809

3. An overview of structural genomics.

Authors: S K Burley
Journal: Nat Struct Biol Date: 2000-11

4. Automated assignment of ambiguous nuclear overhauser effects with ARIA.

Authors: J P Linge; S I O'Donoghue; M Nilges
Journal: Methods Enzymol Date: 2001 Impact factor: 1.600

5. Structures of larger proteins in solution: three- and four-dimensional heteronuclear NMR spectroscopy.

Authors: G M Clore; A M Gronenborn
Journal: Science Date: 1991-06-07 Impact factor: 47.728

Review 6. Determination of three-dimensional structures of proteins and nucleic acids in solution by nuclear magnetic resonance spectroscopy.

Authors: G M Clore; A M Gronenborn
Journal: Crit Rev Biochem Mol Biol Date: 1989 Impact factor: 8.250

7. The application of size exclusion chromatography and computer simulation to study the thermodynamic and kinetic parameters for short-lived dissociable protein aggregates.

Authors: T W Patapoff; R J Mrsny; W A Lee
Journal: Anal Biochem Date: 1993-07 Impact factor: 3.365

8. Study of conformational rearrangement and refinement of structural homology models by the use of heteronuclear dipolar couplings.

Authors: J J Chou; S Li; A Bax
Journal: J Biomol NMR Date: 2000-11 Impact factor: 2.835

9. MS/NMR: a structure-based approach for discovering protein ligands and for drug design by coupling size exclusion chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy.

Authors: F J Moy; K Haraki; D Mobilio; G Walker; R Powers; K Tabei; H Tong; M M Siegel
Journal: Anal Chem Date: 2001-02-01 Impact factor: 6.986

Applications of NMR to structure-based drug design in structural genomics.

Review 1. NMR techniques for characterization of ligand binding: utility for lead generation and optimization in drug discovery.

Review 2. Automated analysis of NMR assignments and structures for proteins.

3. An overview of structural genomics.

4. Automated assignment of ambiguous nuclear overhauser effects with ARIA.

5. Structures of larger proteins in solution: three- and four-dimensional heteronuclear NMR spectroscopy.

Review 6. Determination of three-dimensional structures of proteins and nucleic acids in solution by nuclear magnetic resonance spectroscopy.

7. The application of size exclusion chromatography and computer simulation to study the thermodynamic and kinetic parameters for short-lived dissociable protein aggregates.

8. Study of conformational rearrangement and refinement of structural homology models by the use of heteronuclear dipolar couplings.

9. MS/NMR: a structure-based approach for discovering protein ligands and for drug design by coupling size exclusion chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy.

10. Large-scale protein structure modeling of the Saccharomyces cerevisiae genome.

1. Reduced dimensionality (4,3)D-hnCOCANH experiment: an efficient backbone assignment tool for NMR studies of proteins.

Review 2. Solution NMR Spectroscopy in Target-Based Drug Discovery.

Review 3. What Can Electrochemical Methods Offer in Determining DNA-Drug Interactions?

Review 4. Structural genomics and drug discovery.