Literature DB >> 12836362

Novel taurine-containing uridine derivatives and mitochondrial human diseases.

T Suzuki1, T Suzuki1, T Wada, K Saigo, K Watanabe.   

Abstract

Two novel modified uridines were identified from mammalian mitochondrial (mt) tRNAs. Mass spectrometric analysis revealed that they are modified uridines possessing a sulfonic acid group derived from taurine; 5-taurinomethyl-uridine from mt tRNAs for Trp and Leu(UUR), and 5-taurinomethyl-2-thiouridine from mt tRNAs for Lys, Gln and Glu. We have found lack of modification of these taurine-containing uridines in mutant mt tRNAs for Leu(UUR) and Lys from pathogenic cells of mitochondrial encephalomyopathies, MELAS and MERRF, respectively.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 12836362     DOI： 10.1093/nass/1.1.257

Source DB:  PubMed          Journal:  Nucleic Acids Res Suppl


  10 in total

Review 1.  A compendium of human mitochondrial gene expression machinery with links to disease.

Authors:  Timothy E Shutt; Gerald S Shadel
Journal:  Environ Mol Mutagen       Date:  2010-06       Impact factor: 3.216

Review 2.  Posttranscriptional RNA Modifications: playing metabolic games in a cell's chemical Legoland.

Authors:  Mark Helm; Juan D Alfonzo
Journal:  Chem Biol       Date:  2013-12-05

3.  Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element.

Authors:  Andrea Scrima; Alfred Wittinghofer
Journal:  EMBO J       Date:  2006-06-08       Impact factor: 11.598

Review 4.  Beneficial Effects of Taurine on Metabolic Parameters in Animals and Humans.

Authors:  Minkyung Bae; Kainat Ahmed; Jung-Eun Yim
Journal:  J Obes Metab Syndr       Date:  2022-06-07

5.  Oxidative stress and dysregulation of the taurine transporter in high-glucose-exposed human Schwann cells: implications for pathogenesis of diabetic neuropathy.

Authors:  Trevor Askwith; Wei Zeng; Margaret C Eggo; Martin J Stevens
Journal:  Am J Physiol Endocrinol Metab       Date:  2009-07-14       Impact factor: 4.310

6.  A maternal low protein diet has pronounced effects on mitochondrial gene expression in offspring liver and skeletal muscle; protective effect of taurine.

Authors:  Ole Hartvig Mortensen; Hanne Lodberg Olsen; Lis Frandsen; Peter Eigil Nielsen; Finn Cilius Nielsen; Niels Grunnet; Bjørn Quistorff
Journal:  J Biomed Sci       Date:  2010-08-24       Impact factor: 8.410

7.  The RNA Modification Database, RNAMDB: 2011 update.

Authors:  William A Cantara; Pamela F Crain; Jef Rozenski; James A McCloskey; Kimberly A Harris; Xiaonong Zhang; Franck A P Vendeix; Daniele Fabris; Paul F Agris
Journal:  Nucleic Acids Res       Date:  2010-11-10       Impact factor: 16.971

8.  Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss.

Authors:  Rafaela Andrade-Vieira; Donna Goguen; Heidi A Bentley; Chris V Bowen; Paola A Marignani
Journal:  Oncotarget       Date:  2014-12-30

9.  Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.

Authors:  Sandra Blanco; Sabine Dietmann; Joana V Flores; Shobbir Hussain; Claudia Kutter; Peter Humphreys; Margus Lukk; Patrick Lombard; Lucas Treps; Martyna Popis; Stefanie Kellner; Sabine M Hölter; Lillian Garrett; Wolfgang Wurst; Lore Becker; Thomas Klopstock; Helmut Fuchs; Valerie Gailus-Durner; Martin Hrabĕ de Angelis; Ragnhildur T Káradóttir; Mark Helm; Jernej Ule; Joseph G Gleeson; Duncan T Odom; Michaela Frye
Journal:  EMBO J       Date:  2014-07-25       Impact factor: 11.598

Review 10.  Nucleoside modifications in the regulation of gene expression: focus on tRNA.

Authors:  Markus Duechler; Grażyna Leszczyńska; Elzbieta Sochacka; Barbara Nawrot
Journal:  Cell Mol Life Sci       Date:  2016-04-19       Impact factor: 9.261
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.