Literature DB >> 12823151

Conscious sedation with propofol in elderly patients: a prospective evaluation.

L T Heuss1, P Schnieper, J Drewe, E Pflimlin, C Beglinger.   

Abstract

AIM: To characterize the safety of endoscopic procedures and propofol use as administered by nurses in a cohort of elderly patients.
METHODS: During 19 months all endoscopy patients > 70 years were eligible for this prospective observational study. Patients were assigned to group A (70-85 years) or group B (> 85 years). Records from all patients < 70 years treated during the same period served as controls. Specially trained nurses administered the propofol and monitored for complications (decrease in the peripheral oxygen saturation, mean arterial pressure or heart rate).
RESULTS: There were 1435 endoscopic procedures in group A and 351 in group B. There was no procedure or sedation-related mortality, nor a significantly greater need for emergency intervention than in the control group. Two patients required short mask ventilation but recovered without sequelae. Compared with younger patients, there was a significant increase in risk for a short oxygen desaturation < 90% and a decrease in oxygen saturation > 5%. Arterial hypotension occurred significantly more often in the control group than among the aged patients.
CONCLUSIONS: This present study documents that gastrointestinal endoscopic procedures are safe and well tolerated even in the very elderly. Nurse-administered propofol is a safe and reasonable sedation method in these patients.

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Year:  2003        PMID: 12823151     DOI: 10.1046/j.1365-2036.2003.01608.x

Source DB:  PubMed          Journal:  Aliment Pharmacol Ther        ISSN: 0269-2813            Impact factor:   8.171


  19 in total

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Authors:  L Symington; S Thakore
Journal:  Emerg Med J       Date:  2006-02       Impact factor: 2.740

2.  Nonanesthesiologist-administered propofol versus midazolam and propofol, titrated to moderate sedation, for colonoscopy: a randomized controlled trial.

Authors:  Javier Molina-Infante; Carmen Dueñas-Sadornil; Jose M Mateos-Rodriguez; Belen Perez-Gallardo; Gema Vinagre-Rodríguez; Moises Hernandez-Alonso; Miguel Fernandez-Bermejo; Ferran Gonzalez-Huix
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3.  Effectiveness of outpatient percutaneous endoscopic gastrostomy replacement using esophagogastroduodenoscopy and propofol sedation.

Authors:  Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoki Tanaka
Journal:  World J Gastrointest Endosc       Date:  2012-02-16

4.  Efficacy and Safety of Therapeutic Endoscopic Retrograde Cholangiopancreatography in the Elderly Over 80 Years.

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Journal:  Dig Dis Sci       Date:  2016-02-12       Impact factor: 3.199

Review 5.  Management of lower gastrointestinal bleeding in older adults.

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6.  Stepwise sedation for elderly patients with mild/moderate COPD during upper gastrointestinal endoscopy.

Authors:  Can-Xia Xu; Xiong Chen; Yan Jia; Ding-Hua Xiao; Hui-Fang Zou; Qin Guo; Fen Wang; Xiao-Yan Wang; Shou-Rong Shen; Ling-Ling Tong; Ke Cao; Xiao-Ming Liu
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7.  Performing colonoscopy in elderly and very elderly patients: Risks, costs and benefits.

Authors:  Otto S Lin
Journal:  World J Gastrointest Endosc       Date:  2014-06-16

8.  Bispectral index monitoring for nurse-administered propofol sedation during upper endoscopic ultrasound: a prospective, randomized controlled trial.

Authors:  John M DeWitt
Journal:  Dig Dis Sci       Date:  2008-02-15       Impact factor: 3.199

Review 9.  Monitored anaesthesia care in the elderly: guidelines and recommendations.

Authors:  Margaret Ekstein; Doron Gavish; Tiberiu Ezri; Avi A Weinbroum
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10.  Combined sedation with midazolam/propofol for gastrointestinal endoscopy in elderly patients.

Authors:  Astrid Kerker; Christian Hardt; Hans-Eugen Schlief; Franz Ludwig Dumoulin
Journal:  BMC Gastroenterol       Date:  2010-01-27       Impact factor: 3.067

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