BACKGROUND: Data on the association of n-3 fatty acid content in serum lipids with mortality in patients with coronary artery disease (CAD) are limited. OBJECTIVE: We hypothesized that a high proportion of n-3 fatty acids in serum lipids would be associated with reduced risks of death and coronary events in patients with established CAD. DESIGN: We measured dietary intakes via food records and the fatty acid composition of serum cholesteryl esters (CEs) in 285 men and 130 women with CAD (x age: 61 y; range: 33-74 y). The patients participating in the EUROASPIRE (European Action on Secondary Prevention through Intervention to Reduce Events) study were followed up for 5 y. RESULTS: During the follow-up, 36 patients died, 21 had myocardial infarctions, and 12 had strokes. The relative risks (RRs) of death adjusted for cardiovascular disease risk factors for subjects in the highest tertile of fatty acids in CEs compared with those in the lowest tertile were 0.33 (95% CI: 0.11, 0.96) for alpha-linolenic acid, 0.33 (0.12, 0.93) for eicosapentaenoic acid, and 0.31 (0.11, 0.87) for docosahexaenoic acid (P for trend = 0.063, 0.056, and 0.026, respectively). A high proportion of eicosapentaenoic acid in CEs was associated with a low risk of CAD death. Compared with no consumption, consumption of fish tended to be associated with a lower risk of death [1-57 g/d, RR = 0.50 (0.20, 1.28); > 57 g/d, RR = 0.37 (0.14, 1.00); P for trend = 0.059]. CONCLUSION: High proportions of n-3 fatty acids in serum lipids are associated with a substantially reduced risk of death.
BACKGROUND: Data on the association of n-3 fatty acid content in serum lipids with mortality in patients with coronary artery disease (CAD) are limited. OBJECTIVE: We hypothesized that a high proportion of n-3 fatty acids in serum lipids would be associated with reduced risks of death and coronary events in patients with established CAD. DESIGN: We measured dietary intakes via food records and the fatty acid composition of serum cholesteryl esters (CEs) in 285 men and 130 women with CAD (x age: 61 y; range: 33-74 y). The patients participating in the EUROASPIRE (European Action on Secondary Prevention through Intervention to Reduce Events) study were followed up for 5 y. RESULTS: During the follow-up, 36 patients died, 21 had myocardial infarctions, and 12 had strokes. The relative risks (RRs) of death adjusted for cardiovascular disease risk factors for subjects in the highest tertile of fatty acids in CEs compared with those in the lowest tertile were 0.33 (95% CI: 0.11, 0.96) for alpha-linolenic acid, 0.33 (0.12, 0.93) for eicosapentaenoic acid, and 0.31 (0.11, 0.87) for docosahexaenoic acid (P for trend = 0.063, 0.056, and 0.026, respectively). A high proportion of eicosapentaenoic acid in CEs was associated with a low risk of CAD death. Compared with no consumption, consumption of fish tended to be associated with a lower risk of death [1-57 g/d, RR = 0.50 (0.20, 1.28); > 57 g/d, RR = 0.37 (0.14, 1.00); P for trend = 0.059]. CONCLUSION: High proportions of n-3 fatty acids in serum lipids are associated with a substantially reduced risk of death.
Authors: Cristina Razquin; Liming Liang; Estefanía Toledo; Clary B Clish; Miguel Ruiz-Canela; Yan Zheng; Dong D Wang; Dolores Corella; Olga Castaner; Emilio Ros; Fernando Aros; Enrique Gomez-Gracia; Miquel Fiol; José Manuel Santos-Lozano; Marta Guasch-Ferre; Lluis Serra-Majem; Aleix Sala-Vila; Pilar Buil-Cosiales; Monica Bullo; Montserrat Fito; Olga Portoles; Ramon Estruch; Jordi Salas-Salvado; Frank B Hu; Miguel A Martinez-Gonzalez Journal: Int J Cardiol Date: 2018-02-15 Impact factor: 4.164
Authors: Dariush Mozaffarian; Rozenn N Lemaitre; Irena B King; Xiaoling Song; Hongyan Huang; Frank M Sacks; Eric B Rimm; Molin Wang; David S Siscovick Journal: Ann Intern Med Date: 2013-04-02 Impact factor: 25.391
Authors: Edel O Elvevoll; Harald Barstad; Einar S Breimo; Jan Brox; Karl-Erik Eilertsen; Trine Lund; Jan Ole Olsen; Bjarne Osterud Journal: Lipids Date: 2006-12 Impact factor: 1.880
Authors: Eric B Rimm; Lawrence J Appel; Stephanie E Chiuve; Luc Djoussé; Mary B Engler; Penny M Kris-Etherton; Dariush Mozaffarian; David S Siscovick; Alice H Lichtenstein Journal: Circulation Date: 2018-05-17 Impact factor: 29.690