Literature DB >> 21076723

The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid.

Delfin Rodriguez-Leyva1, Chantal M C Dupasquier, Richelle McCullough, Grant N Pierce.   

Abstract

Preventing the occurrence of cardiovascular disease (CVD) with nutritional interventions is a therapeutic strategy that may warrant greater research attention. The increased use of omega (ω)-3 fatty acids is a powerful example of one such nutritional strategy that may produce significant cardiovascular benefits. Marine food products have provided the traditional dietary sources of ω-3 fatty acids. Flaxseed is an alternative to marine products. It is one of the richest sources of the plant-based ω-3 fatty acid, alpha-linolenic acid (ALA). Based on the results of clinical trials, epidemiological investigations and experimental studies, ingestion of ALA has been suggested to have a positive impact on CVD. Because of its high ALA content, the use of flaxseed has been advocated to combat CVD. The purpose of the present review was to identify the known cardiovascular effects of flaxseed and ALA and, just as importantly, what is presently unknown.

Entities:  

Mesh:

Substances:

Year:  2010        PMID: 21076723      PMCID: PMC2989356          DOI: 10.1016/s0828-282x(10)70455-4

Source DB:  PubMed          Journal:  Can J Cardiol        ISSN: 0828-282X            Impact factor:   5.223


  105 in total

1.  Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial.

Authors:  T A Dolecek
Journal:  Proc Soc Exp Biol Med       Date:  1992-06

Review 2.  Human requirement for N-3 polyunsaturated fatty acids.

Authors:  A P Simopoulos
Journal:  Poult Sci       Date:  2000-07       Impact factor: 3.352

3.  Nutritional attributes of traditional flaxseed in healthy young adults.

Authors:  S C Cunnane; M J Hamadeh; A C Liede; L U Thompson; T M Wolever; D J Jenkins
Journal:  Am J Clin Nutr       Date:  1995-01       Impact factor: 7.045

4.  Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients.

Authors:  G K Paschos; F Magkos; D B Panagiotakos; V Votteas; A Zampelas
Journal:  Eur J Clin Nutr       Date:  2007-01-31       Impact factor: 4.016

5.  Flaxseed in lupus nephritis: a two-year nonplacebo-controlled crossover study.

Authors:  W F Clark; C Kortas; A P Heidenheim; J Garland; E Spanner; A Parbtani
Journal:  J Am Coll Nutr       Date:  2001-04       Impact factor: 3.169

6.  Flaxseed consumption influences endogenous hormone concentrations in postmenopausal women.

Authors:  A M Hutchins; M C Martini; B A Olson; W Thomas; J L Slavin
Journal:  Nutr Cancer       Date:  2001       Impact factor: 2.900

7.  A multi-country health-economic evaluation of highly concentrated n-3 polyunsaturated fatty acids in the secondary prevention after myocardial infarction.

Authors:  Mark Lamotte; Lieven Annemans; Pawel Kawalec; York Zoellners
Journal:  Herz       Date:  2006-12       Impact factor: 1.443

8.  Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial.

Authors:  Sylvie Dodin; Stephen C Cunnane; Benoît Mâsse; André Lemay; Hélène Jacques; Geneviève Asselin; Jennifer Tremblay-Mercier; Isabelle Marc; Benoît Lamarche; France Légaré; Jean-Claude Forest
Journal:  Nutrition       Date:  2007-11-05       Impact factor: 4.008

9.  Regulation of PUFA metabolism: pharmacological and toxicological aspects.

Authors:  P Risé; F Marangoni; C Galli
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  2002 Aug-Sep       Impact factor: 4.006

10.  Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions.

Authors:  Chantal M C Dupasquier; Elena Dibrov; Annette L Kneesh; Paul K M Cheung; Kaitlin G Y Lee; Helen K Alexander; Behzad K Yeganeh; Mohammed H Moghadasian; Grant N Pierce
Journal:  Am J Physiol Heart Circ Physiol       Date:  2007-07-06       Impact factor: 4.733

View more
  38 in total

1.  Augmented bioavailability of felodipine through an α-linolenic acid-based microemulsion.

Authors:  Mahendra Singh; Jovita Kanoujia; Poonam Parashar; Malti Arya; Chandra B Tripathi; V R Sinha; Shailendra K Saraf; Shubhini A Saraf
Journal:  Drug Deliv Transl Res       Date:  2018-02       Impact factor: 4.617

2.  Development of stable flaxseed oil emulsions as a potential delivery system of ω-3 fatty acids.

Authors:  Ankit Goyal; Vivek Sharma; Neelam Upadhyay; A K Singh; Sumit Arora; Darshan Lal; Latha Sabikhi
Journal:  J Food Sci Technol       Date:  2014-09-02       Impact factor: 2.701

3.  Interactions of linoleic and alpha-linolenic acids in the development of fatty acid alterations in cystic fibrosis.

Authors:  Waddah Katrangi; Joshua Lawrenz; Adam C Seegmiller; Michael Laposata
Journal:  Lipids       Date:  2013-02-27       Impact factor: 1.880

4.  Long term consumption of flaxseed enriched diet decreased ovarian cancer incidence and prostaglandin E₂in hens.

Authors:  Erfan Eilati; Janice M Bahr; Dale Buchanan Hales
Journal:  Gynecol Oncol       Date:  2013-05-23       Impact factor: 5.482

Review 5.  Unified theory of Alzheimer's disease (UTAD): implications for prevention and curative therapy.

Authors:  Michael Nehls
Journal:  J Mol Psychiatry       Date:  2016-07-15

6.  Inflammation in depression: is adiposity a cause?

Authors:  Richard C Shelton; Andrew H Miller
Journal:  Dialogues Clin Neurosci       Date:  2011       Impact factor: 5.986

7.  Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice.

Authors:  Melpo Christofidou-Solomidou; Sonia Tyagi; Kay-See Tan; Sarah Hagan; Ralph Pietrofesa; Floyd Dukes; Evguenia Arguiri; Daniel F Heitjan; Charalambos C Solomides; Keith A Cengel
Journal:  BMC Cancer       Date:  2011-06-24       Impact factor: 4.430

8.  Effect of flaxseed supplementation and exercise training on lipid profile, oxidative stress and inflammation in rats with myocardial ischemia.

Authors:  Howaida A Nounou; Maha M Deif; Manal A Shalaby
Journal:  Lipids Health Dis       Date:  2012-10-05       Impact factor: 3.876

9.  Flaxseed oil and α-lipoic acid combination reduces atherosclerosis risk factors in rats fed a high-fat diet.

Authors:  Jiqu Xu; Wei Yang; Qianchun Deng; Qingde Huang; Jin'e Yang; Fenghong Huang
Journal:  Lipids Health Dis       Date:  2012-10-31       Impact factor: 3.876

10.  Complementary and alternative medicine and cardiovascular disease: an evidence-based review.

Authors:  Matthew J Rabito; Alan David Kaye
Journal:  Evid Based Complement Alternat Med       Date:  2013-04-22       Impact factor: 2.629

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.