Literature DB >> 12798676

Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria.

Jan Piwowarski1, Pawel Grzechnik, Andrzej Dziembowski, Aleksandra Dmochowska, Michal Minczuk, Piotr P Stepien.   

Abstract

The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.

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Year:  2003        PMID： 12798676     DOI： 10.1016/s0022-2836(03)00528-x

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  33 in total

1.  Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase.

Authors:  Rafal Tomecki; Aleksandra Dmochowska; Kamil Gewartowski; Andrzej Dziembowski; Piotr P Stepien
Journal:  Nucleic Acids Res       Date:  2004-11-16       Impact factor: 16.971

2.  Polyadenylation and degradation of human mitochondrial RNA: the prokaryotic past leaves its mark.

Authors:  Shimyn Slomovic; David Laufer; Dan Geiger; Gadi Schuster
Journal:  Mol Cell Biol       Date:  2005-08       Impact factor: 4.272

3.  A new function in translocation for the mitochondrial i-AAA protease Yme1: import of polynucleotide phosphorylase into the intermembrane space.

Authors:  Robert N Rainey; Jenny D Glavin; Hsiao-Wen Chen; Samuel W French; Michael A Teitell; Carla M Koehler
Journal:  Mol Cell Biol       Date:  2006-09-11       Impact factor: 4.272

4.  Balance between transcription and RNA degradation is vital for Saccharomyces cerevisiae mitochondria: reduced transcription rescues the phenotype of deficient RNA degradation.

Authors:  Agata T Rogowska; Olga Puchta; Anna M Czarnecka; Aneta Kaniak; Piotr P Stepien; Pawel Golik
Journal:  Mol Biol Cell       Date:  2005-12-21       Impact factor: 4.138

Review 5.  Regulation of Mammalian Mitochondrial Gene Expression: Recent Advances.

Authors:  Sarah F Pearce; Pedro Rebelo-Guiomar; Aaron R D'Souza; Christopher A Powell; Lindsey Van Haute; Michal Minczuk
Journal:  Trends Biochem Sci       Date:  2017-03-09       Impact factor: 13.807

Review 6.  A compendium of human mitochondrial gene expression machinery with links to disease.

Authors:  Timothy E Shutt; Gerald S Shadel
Journal:  Environ Mol Mutagen       Date:  2010-06       Impact factor: 3.216

7.  Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis.

Authors:  Hsiao-Wen Chen; Robert N Rainey; Cynthia E Balatoni; David W Dawson; Joshua J Troke; Sylwia Wasiak; Jason S Hong; Heidi M McBride; Carla M Koehler; Michael A Teitell; Samuel W French
Journal:  Mol Cell Biol       Date:  2006-09-11       Impact factor: 4.272

8.  Crystal structure of Escherichia coli PNPase: central channel residues are involved in processive RNA degradation.

Authors:  Zhonghao Shi; Wei-Zen Yang; Sue Lin-Chao; Kin-Fu Chak; Hanna S Yuan
Journal:  RNA       Date:  2008-09-23       Impact factor: 4.942

9.  Mitochondrial BMI1 maintains bioenergetic homeostasis in cells.

Authors:  Soumyajit Banerjee Mustafi; Nicolas Aznar; Shailendra Kumar Dhar Dwivedi; Prabir Kumar Chakraborty; Rumki Basak; Priyabrata Mukherjee; Pradipta Ghosh; Resham Bhattacharya
Journal:  FASEB J       Date:  2016-09-09       Impact factor: 5.191

10.  Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance.

Authors:  Roman J Szczesny; Lukasz S Borowski; Lien K Brzezniak; Aleksandra Dmochowska; Kamil Gewartowski; Ewa Bartnik; Piotr P Stepien
Journal:  Nucleic Acids Res       Date:  2009-10-28       Impact factor: 16.971
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