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Literature DB >> 12797775

A new strategy for improved nicotine vaccines using conformationally constrained haptens.

Michael M Meijler¹, Masayuki Matsushita, Laurence J Altobell, Peter Wirsching, Kim D Janda.

Abstract

Constrained nicotine analogues were synthesized and coupled to the carrier protein KLH. The immunogenic effects were compared to those using our previously designed flexible nicotine hapten. Immunization of mice with the constrained hapten conjugates resulted in highly increased antibody titers and affinity for nicotine.

Entities: Chemical Species

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Year: 2003 PMID： 12797775 DOI： 10.1021/ja034805t

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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Cited

18 in total

1. Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats.

Authors: Mark G LeSage; Daniel E Keyler; Yoko Hieda; Greg Collins; Danielle Burroughs; Chap Le; Paul R Pentel
Journal: Psychopharmacology (Berl) Date: 2005-07-01 Impact factor: 4.530

Review 2. Current status of immunologic approaches to treating tobacco dependence: vaccines and nicotine-specific antibodies.

Authors: Mark G LeSage; Daniel E Keyler; Paul R Pentel
Journal: AAPS J Date: 2006-02-24 Impact factor: 4.009

Review 3. Conjugate Vaccine Immunotherapy for Substance Use Disorder.

Authors: Paul T Bremer; Kim D Janda
Journal: Pharmacol Rev Date: 2017-07 Impact factor: 25.468

Review 4. Vaccines against drugs of abuse: where are we now?

Authors: Berma Kinsey
Journal: Ther Adv Vaccines Date: 2014-07

5. Structurally distinct nicotine immunogens elicit antibodies with non-overlapping specificities.

Authors: M Pravetoni; D E Keyler; R R Pidaparthi; F I Carroll; S P Runyon; M P Murtaugh; C A Earley; P R Pentel
Journal: Biochem Pharmacol Date: 2011-11-15 Impact factor: 5.858

6. Expeditious synthesis of cis-1-methyl-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo-[3,2h]isoquinoline / [2,3-f]quinoline via azomethine ylide-alkene [3+2] cycloaddition.

Authors: Zhenfa Zhang; Linda P Dwoskin; Peter A Crooks
Journal: Tetrahedron Lett Date: 2011-05-25 Impact factor: 2.415

A new strategy for improved nicotine vaccines using conformationally constrained haptens.

1. Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats.

Review 2. Current status of immunologic approaches to treating tobacco dependence: vaccines and nicotine-specific antibodies.

Review 3. Conjugate Vaccine Immunotherapy for Substance Use Disorder.

Review 4. Vaccines against drugs of abuse: where are we now?

5. Structurally distinct nicotine immunogens elicit antibodies with non-overlapping specificities.

6. Expeditious synthesis of cis-1-methyl-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo-[3,2h]isoquinoline / [2,3-f]quinoline via azomethine ylide-alkene [3+2] cycloaddition.

Review 7. Immunopharmacotherapy: vaccination strategies as a treatment for drug abuse and dependence.

8. Enhancing nicotine vaccine immunogenicity with liposomes.

Review 9. Advances in smoking cessation pharmacotherapy: Non-nicotinic approaches in animal models.

10. Prevention of drug-induced memory impairment by immunopharmacotherapy.