Literature DB >> 24982760

Vaccines against drugs of abuse: where are we now?

Berma Kinsey1.   

Abstract

Drug addiction is a serious problem worldwide. One therapy being investigated is vaccines against drugs of abuse. The antibodies elicited against the drug can take up the drug and prevent it from reaching the reward centers in the brain. Few such vaccines have entered clinical trials, but research is going on apace. Many studies are very promising and more clinical trials should be coming out in the near future.

Entities:  

Keywords:  antibodies; drugs; vaccines

Year:  2014        PMID： 24982760      PMCID： PMC4063243          DOI： 10.1177/2051013614537818

Source DB:  PubMed          Journal:  Ther Adv Vaccines        ISSN： 2051-0136


  90 in total

1.  Dynamic vaccine blocks relapse to compulsive intake of heroin.

Authors:  Joel E Schlosburg; Leandro F Vendruscolo; Paul T Bremer; Jonathan W Lockner; Carrie L Wade; Ashlee A K Nunes; G Neil Stowe; Scott Edwards; Kim D Janda; George F Koob
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-06       Impact factor: 11.205

2.  Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity.

Authors:  Bishnu P De; Odelya E Pagovich; Martin J Hicks; Jonathan B Rosenberg; Amira Y Moreno; Kim D Janda; George F Koob; Stefan Worgall; Stephen M Kaminsky; Dolan Sondhi; Ronald G Crystal
Journal:  Hum Gene Ther       Date:  2012-12-21       Impact factor: 5.695

3.  Antibodies to morphine in workers exposed to opiates at a narcotics manufacturing facility and evidence for similar antibodies in heroin abusers.

Authors:  R E Biagini; S L Klincewicz; G M Henningsen; B A MacKenzie; J S Gallagher; D I Bernstein; I L Bernstein
Journal:  Life Sci       Date:  1990       Impact factor: 5.037

4.  An immunotherapeutic program for the treatment of nicotine addiction: hapten design and synthesis.

Authors:  S Isomura; P Wirsching; K D Janda
Journal:  J Org Chem       Date:  2001-06-15       Impact factor: 4.354

5.  A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats.

Authors:  Michelle L Miller; Amira Y Moreno; Shawn M Aarde; Kevin M Creehan; Sophia A Vandewater; Brittani D Vaillancourt; M Jerry Wright; Kim D Janda; Michael A Taffe
Journal:  Biol Psychiatry       Date:  2012-10-23       Impact factor: 13.382

6.  Delayed clearance of morphine from the circulation of rabbits immunized with morphine-6-hemisuccinate bovine serum albumin.

Authors:  J H Hill; B H Wainer; F W Fitch; R M Rothberg
Journal:  J Immunol       Date:  1975-04       Impact factor: 5.422

Review 7.  Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse.

Authors:  Stephen Brimijoin; Xiaoyun Shen; Frank Orson; Thomas Kosten
Journal:  Expert Rev Vaccines       Date:  2013-03       Impact factor: 5.217

8.  Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens.

Authors:  Marco Pravetoni; Morgan Le Naour; Ashli M Tucker; Theresa M Harmon; Tara M Hawley; Philip S Portoghese; Paul R Pentel
Journal:  J Med Chem       Date:  2013-01-15       Impact factor: 7.446

9.  A novel bivalent morphine/heroin vaccine that prevents relapse to heroin addiction in rodents.

Authors:  Benito Anton; Philippe Leff
Journal:  Vaccine       Date:  2006-02-08       Impact factor: 3.641

10.  High immunogenicity of nicotine vaccines obtained by intradermal delivery with safe adjuvants.

Authors:  Xinyuan Chen; Marco Pravetoni; Brijesh Bhayana; Paul R Pentel; Mei X Wu
Journal:  Vaccine       Date:  2012-10-30       Impact factor: 3.641
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  14 in total

1.  Investigations into the efficacy of multi-component cocaine vaccines.

Authors:  Atsushi Kimishima; Margaret E Olson; Kim D Janda
Journal:  Bioorg Med Chem Lett       Date:  2017-12-20       Impact factor: 2.823

2.  Optimization of a multivalent peptide vaccine for nicotine addiction.

Authors:  David F Zeigler; Richard Roque; Christopher H Clegg
Journal:  Vaccine       Date:  2019-02-13       Impact factor: 3.641

3.  Efficacy, but not antibody titer or affinity, of a heroin hapten conjugate vaccine correlates with increasing hapten densities on tetanus toxoid, but not on CRM197 carriers.

Authors:  Rashmi Jalah; Oscar B Torres; Alexander V Mayorov; Fuying Li; Joshua F G Antoline; Arthur E Jacobson; Kenner C Rice; Jeffrey R Deschamps; Zoltan Beck; Carl R Alving; Gary R Matyas
Journal:  Bioconjug Chem       Date:  2015-06-05       Impact factor: 4.774

Review 4.  Current approaches for the discovery of drugs that deter substance and drug abuse.

Authors:  Adam Yasgar; Anton Simeonov
Journal:  Expert Opin Drug Discov       Date:  2014-09-24       Impact factor: 6.098

Review 5.  Biologics to treat substance use disorders: Current status and new directions.

Authors:  Marco Pravetoni
Journal:  Hum Vaccin Immunother       Date:  2016-07-21       Impact factor: 3.452

6.  Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric hapten design and combinatorial vaccination.

Authors:  Cody J Wenthur; Xiaoqing Cai; Beverly A Ellis; Kim D Janda
Journal:  Bioorg Med Chem Lett       Date:  2017-07-05       Impact factor: 2.823

7.  Promising roles for pharmacists in addressing the U.S. opioid crisis.

Authors:  Wilson M Compton; Christopher M Jones; Jack B Stein; Eric M Wargo
Journal:  Res Social Adm Pharm       Date:  2017-12-31

8.  Pharmacotherapy of Patients Taking New Psychoactive Substances: A Systematic Review and Analysis of Case Reports.

Authors:  Michal Ordak; Aleksandra Zmysłowska; Miłosz Bielski; Daniel Rybak; Maja Tomaszewska; Katarzyna Wyszomierska; Aleksandra Kmiec; Natalia Garlicka; Maria Zalewska; Michal Zalewski; Tadeusz Nasierowski; Elzbieta Muszynska; Magdalena Bujalska-Zadrozny
Journal:  Front Psychiatry       Date:  2021-04-23       Impact factor: 4.157

9.  Ethical Implications in Vaccine Pharmacotherapy for Treatment and Prevention of Drug of Abuse Dependence.

Authors:  Anna Carfora; Paola Cassandro; Alessandro Feola; Francesco La Sala; Raffaella Petrella; Renata Borriello
Journal:  J Bioeth Inq       Date:  2018-01-19       Impact factor: 1.352

10.  Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques.

Authors:  Suzette M Evans; Richard W Foltin; Martin J Hicks; Jonathan B Rosenberg; Bishnu P De; Kim D Janda; Stephen M Kaminsky; Ronald G Crystal
Journal:  Pharmacol Biochem Behav       Date:  2016-09-30       Impact factor: 3.533
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