OBJECTIVE: To assess the impact of iron loading on the activity of isoniazid and ethambutol in the treatment of murine tuberculosis. DESIGN: Iron-loaded and iron-normal female Balb/C mice infected with 1.5 x 10(7) colony forming units of Mycobacterium tuberculosis were treated with either isoniazid or ethambutol for 28 days. RESULTS: For both treatments, the outcome was impaired by the iron loading: bactericidal activity of isoniazid was partially but significantly reduced and ethambutol bactericidal activity was totally inhibited. CONCLUSION: The treatment of tuberculosis in patients with iron loading should be longer than for normal patients or should contain an additional drug.
OBJECTIVE: To assess the impact of iron loading on the activity of isoniazid and ethambutol in the treatment of murinetuberculosis. DESIGN:Iron-loaded and iron-normal female Balb/C mice infected with 1.5 x 10(7) colony forming units of Mycobacterium tuberculosis were treated with either isoniazid or ethambutol for 28 days. RESULTS: For both treatments, the outcome was impaired by the iron loading: bactericidal activity of isoniazid was partially but significantly reduced and ethambutol bactericidal activity was totally inhibited. CONCLUSION: The treatment of tuberculosis in patients with iron loading should be longer than for normal patients or should contain an additional drug.
Authors: James Joseph Phelan; Kate McQuaid; Colin Kenny; Karl Michael Gogan; Dónal J Cox; Sharee Ann Basdeo; Seónadh O'Leary; Simone Christa Tazoll; Cilian Ó Maoldomhnaigh; Mary P O'Sullivan; Luke A O'Neill; Maureen J O'Sullivan; Joseph Keane Journal: Front Immunol Date: 2020-05-13 Impact factor: 7.561
Authors: Sogol Alebouyeh; Jorge A Cárdenas-Pestana; Lucia Vazquez; Rafael Prados-Rosales; Patricia Del Portillo; Joaquín Sanz; Maria Carmen Menéndez; Maria J García Journal: Front Microbiol Date: 2022-10-04 Impact factor: 6.064
Authors: Joann M McDermid; Branwen J Hennig; Marianne van der Sande; Adrian V S Hill; Hilton C Whittle; Assan Jaye; Andrew M Prentice Journal: BMC Infect Dis Date: 2013-01-29 Impact factor: 3.090
Authors: James J Phelan; Sharee A Basdeo; Simone C Tazoll; Sadhbh McGivern; Judit R Saborido; Joseph Keane Journal: Front Immunol Date: 2018-10-15 Impact factor: 7.561
Authors: Vineel P Reddy; Krishna C Chinta; Vikram Saini; Joel N Glasgow; Travis D Hull; Amie Traylor; Fernanda Rey-Stolle; Miguel P Soares; Rajhmun Madansein; Md Aejazur Rahman; Coral Barbas; Kievershen Nargan; Threnesan Naidoo; Pratistadevi K Ramdial; James F George; Anupam Agarwal; Adrie J C Steyn Journal: Front Immunol Date: 2018-05-03 Impact factor: 7.561