Literature DB >> 22033148

Iron metabolism and the innate immune response to infection.

Erin E Johnson1, Marianne Wessling-Resnick.   

Abstract

Host antimicrobial mechanisms reduce iron availability to pathogens. Iron proteins influencing the innate immune response include hepcidin, lactoferrin, siderocalin, haptoglobin, hemopexin, Nramp1, ferroportin and the transferrin receptor. Numerous global health threats are influenced by iron status and provide examples of our growing understanding of the connections between infection and iron metabolism.
Copyright © 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

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Year:  2011        PMID: 22033148      PMCID: PMC3270215          DOI: 10.1016/j.micinf.2011.10.001

Source DB:  PubMed          Journal:  Microbes Infect        ISSN: 1286-4579            Impact factor:   2.700


  115 in total

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2.  Expression of lactoferrin on human granulocytes: analysis with polyclonal and monoclonal antibodies.

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4.  Leishmania chagasi: effect of the iron deficiency on the infection in BALB/c mice.

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Review 7.  Iron delocalisation in the pathogenesis of malarial anaemia.

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9.  Slc11a1 limits intracellular growth of Salmonella enterica sv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition.

Authors:  Manfred Nairz; Gernot Fritsche; Marie-Laure V Crouch; Howard C Barton; Ferric C Fang; Günter Weiss
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Authors:  Ulrich E Schaible; Helen L Collins; Friedrich Priem; Stefan H E Kaufmann
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4.  Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.

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6.  Intranasal Lactoferrin Enhances α-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1α Pathways in an Alzheimer's Disease Mouse Model.

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7.  Association between maternal iron supplementation during pregnancy and risk of celiac disease in children.

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Review 10.  Vibrio Iron Transport: Evolutionary Adaptation to Life in Multiple Environments.

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