Why patients don't take part in cancer clinical trials: an overview of the literature.

Clinical trials have been recognized extensively within the literature as a crucial component in the research, development and evaluation of treatment strategies within health care services. However, it has also been acknowledged that clinicians and researchers have historically experienced problems in terms of attaining adequate recruitment to clinical trials. The purpose of this review is to explore some of these questions and, more importantly, provide possible explanations for non-participation in clinical trials, with specific reference to the field of cancer research. In addition, approaches that have been used by researchers in order to explore the issue of non-participation, and suggestions in terms of the ways that further research into this key area may be undertaken, are also be considered.