Literature DB >> 12779114

Paradoxical reactions to benzodiazepines in intravenous sedation: a report of 2 cases and review of the literature.

Christian Robin1, Norman Trieger.   

Abstract

Paradoxical reactions to benzodiazepines have been thoroughly reported since the introduction of this type of drug. The mechanism of benzodiazepine action is through the gamma-aminobutyric acid receptors. Properties of benzodiazepine include sedation, anxiolysis, amnesia, anticonvulsion, and muscle relaxation. Unfortunately, adverse paradoxical reactions can be stimulated by benzodiazepines and are difficult to predict and diagnose. Two cases of paradoxical reactions associated with the use of intravenous midazolam are presented, and the management of this complication and its different etiologies are reviewed. The relationship of the paradoxical reaction to alteration of the cholinergic homeostasis, serotonin levels, the role of genetics, and gamma-aminobutyric acid receptor configuration is discussed.

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Year:  2002        PMID： 12779114      PMCID： PMC2007411     

Source DB:  PubMed          Journal:  Anesth Prog        ISSN： 0003-3006


  20 in total

1.  Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

Authors:  S J Mihic; Q Ye; M J Wick; V V Koltchine; M D Krasowski; S E Finn; M P Mascia; C F Valenzuela; K K Hanson; E P Greenblatt; R A Harris; N L Harrison
Journal:  Nature       Date:  1997-09-25       Impact factor: 49.962

2.  Differential expression of GABAA receptor alpha-subunits in rat brain during development.

Authors:  R M McKernan; P Cox; N P Gillard; P Whiting
Journal:  FEBS Lett       Date:  1991-07-29       Impact factor: 4.124

3.  Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits.

Authors:  J A Benson; K Löw; R Keist; H Mohler; U Rudolph
Journal:  FEBS Lett       Date:  1998-07-24       Impact factor: 4.124

4.  The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid.

Authors:  D Belelli; J J Lambert; J A Peters; K Wafford; P J Whiting
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-30       Impact factor: 11.205

Review 5.  Disinhibitory reactions to benzodiazepines: a review.

Authors:  P van der Bijl; J A Roelofse
Journal:  J Oral Maxillofac Surg       Date:  1991-05       Impact factor: 1.895

6.  Paradoxical reactions in children associated with midazolam use during endoscopy.

Authors:  M Massanari; J Novitsky; L J Reinstein
Journal:  Clin Pediatr (Phila)       Date:  1997-12       Impact factor: 1.168

Review 7.  Molecular and functional diversity of the expanding GABA-A receptor gene family.

Authors:  P J Whiting; T P Bonnert; R M McKernan; S Farrar; B Le Bourdellès; R P Heavens; D W Smith; L Hewson; M R Rigby; D J Sirinathsinghji; S A Thompson; K A Wafford
Journal:  Ann N Y Acad Sci       Date:  1999-04-30       Impact factor: 5.691

Review 8.  [Violent paradoxal reactions secondary to the use of benzodiazepines].

Authors:  J L Senninger; M Laxenaire
Journal:  Ann Med Psychol (Paris)       Date:  1995-04       Impact factor: 0.380

9.  Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination.

Authors:  S A Thompson; P J Whiting; K A Wafford
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

10.  Flumazenil reverses paradoxical reaction with midazolam.

Authors:  C R Rodrigo
Journal:  Anesth Prog       Date:  1991 Mar-Apr
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  18 in total

1.  Sedation-related complications in gastrointestinal endoscopy.

Authors:  Somchai Amornyotin
Journal:  World J Gastrointest Endosc       Date:  2013-11-16

2.  The effect of midazolam dose and age on the paradoxical midazolam reaction in Korean pediatric patients.

Authors:  Young Hee Shin; Myung Hee Kim; Jung Jin Lee; Soo Joo Choi; Mi Sook Gwak; Ae Ryoung Lee; Mi Na Park; Hyo Sung Joo; Jung Hee Choi
Journal:  Korean J Anesthesiol       Date:  2013-07-19

3.  Paradoxical reaction to midazolam reversed with flumazenil.

Authors:  Luciano Santana Cabrera; Ana Sánchez Santana; Pilar Eugenio Robaina; Manuel Sánchez Palacios
Journal:  J Emerg Trauma Shock       Date:  2010-07

4.  Bacopa monniera exerts antiamnesic effect on diazepam-induced anterograde amnesia in mice.

Authors:  Sudesh Prabhakar; Manish Kumar Saraf; Promila Pandhi; Akshay Anand
Journal:  Psychopharmacology (Berl)       Date:  2008-01-13       Impact factor: 4.530

5.  Comparison between dexmedetomidine and midazolam as a sedation agent with local anesthesia in inguinal hernia repair: randomized controlled trial.

Authors:  T Mishina; T Aiba; K Hiramatsu; Y Shibata; M Yoshihara; T Aoba; N Yamaguchi; T Kato
Journal:  Hernia       Date:  2017-09-30       Impact factor: 4.739

6.  Risk factors and outcomes after unplanned extubations on the ICU: a case-control study.

Authors:  Robin I de Groot; Olaf M Dekkers; Ingeborg Hf Herold; Evert de Jonge; M Sesmu Arbous
Journal:  Crit Care       Date:  2011-01-13       Impact factor: 9.097

7.  The effect of dexmedetomidine as an adjuvant to ropivacaine on the bispectral index for supraclavicular brachial plexus block.

Authors:  Youngsuk Kwon; Sung Mi Hwang; Jae Jun Lee; Jong Ho Kim
Journal:  Korean J Anesthesiol       Date:  2015-01-28

8.  Comparative Evaluation of Dexmedetomidine and Propofol Along With Scalp Block on Haemodynamic and Postoperative Recovery for Chronic Subdural Haematoma Evacuation Under Monitored Anaesthesia Care.

Authors:  Vinit Kumar Srivastava; Sanjay Agrawal; Sanjay Kumar; Saima Khan; Sunil Sharma; Raj Kumar
Journal:  Turk J Anaesthesiol Reanim       Date:  2018-02-01

9.  Are Histrionic Personality Traits Associated with Irritability during Conscious Sedation Endoscopy?

Authors:  Sang Shin Lee; Hyung Hun Kim; Hyo Jung Park
Journal:  Gastroenterol Res Pract       Date:  2015-04-12       Impact factor: 2.260

10.  Paradoxical Reaction to Alprazolam in an Elderly Woman with a History of Anxiety, Mood Disorders, and Hypothyroidism.

Authors:  Daniel Kirkpatrick; Tyler Smith; Mitchell Kerfeld; Taylor Ramsdell; Hasnain Sadiq; Arun Sharma
Journal:  Case Rep Psychiatry       Date:  2016-03-22
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