Flumazenil reverses paradoxical reaction with midazolam.

A European female sedated with midazolam developed severe aggressive behavior during insertion of implants, which increased with further increments of midazolam. This paradoxical reaction was terminated by the injection of flumazenil, after which the patient calmly underwent the procedure. At the end of the procedure she was found to have amnesia from the time of initial injection of midazolam to the end of the implant procedure.