RATIONALE: Serotonin (5-HT) is involved in the control of eating behaviour by inhibiting food intake. Obese women with binge-eating disorder (OB-BED) were recently found to have reduced 5-HT transporter binding. OBJECTIVES: The aim of this study was to investigate the effect of a successful treatment on 5-HT transporters in OB-BED. METHODS: The 5-HT transporter binding of seven OB-BED was measured by single-photon emission computed tomography (SPECT), by using iodine-123-labelled nor-beta-CIT as a tracer, before treatment and after successful treatment, when the OB-BED were asymptomatic. Treatment consisted of group psychotherapy and fluoxetine medication. The control subjects, six obese women without eating disorders, were also studied twice by using SPECT. RESULTS: The 5-HT transporter binding of the symptomatically recovered OB-BED increased significantly (24+/-22%) after treatment, whereas in the control group, binding remained unchanged. CONCLUSIONS: The results tentatively suggest that 5-HT transporter binding in OB-BED is an adaptive mechanism, which can be affected by treatment. Furthermore, there seems to be a link between improved 5-HT transporter binding and reduced binge eating.
RATIONALE: Serotonin (5-HT) is involved in the control of eating behaviour by inhibiting food intake. Obesewomen with binge-eating disorder (OB-BED) were recently found to have reduced 5-HT transporter binding. OBJECTIVES: The aim of this study was to investigate the effect of a successful treatment on 5-HT transporters in OB-BED. METHODS: The 5-HT transporter binding of seven OB-BED was measured by single-photon emission computed tomography (SPECT), by using iodine-123-labelled nor-beta-CIT as a tracer, before treatment and after successful treatment, when the OB-BED were asymptomatic. Treatment consisted of group psychotherapy and fluoxetine medication. The control subjects, six obesewomen without eating disorders, were also studied twice by using SPECT. RESULTS: The 5-HT transporter binding of the symptomatically recovered OB-BED increased significantly (24+/-22%) after treatment, whereas in the control group, binding remained unchanged. CONCLUSIONS: The results tentatively suggest that 5-HT transporter binding in OB-BED is an adaptive mechanism, which can be affected by treatment. Furthermore, there seems to be a link between improved 5-HT transporter binding and reduced binge eating.
Authors: J T Kuikka; L Tammela; L Karhunen; A Rissanen; K A Bergström; H Naukkarinen; E Vanninen; J Karhu; R Lappalainen; E Repo-Tiihonen; J Tiihonen; M Uusitupa Journal: Psychopharmacology (Berl) Date: 2001-05 Impact factor: 4.530
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Authors: R L Spitzer; S Yanovski; T Wadden; R Wing; M D Marcus; A Stunkard; M Devlin; J Mitchell; D Hasin; R L Horne Journal: Int J Eat Disord Date: 1993-03 Impact factor: 4.861
Authors: C H van Dyck; R T Malison; J P Seibyl; M Laruelle; H Klumpp; S S Zoghbi; R M Baldwin; R B Innis Journal: Neurobiol Aging Date: 2000 Jul-Aug Impact factor: 4.673
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