Literature DB >> 11504089

Effects of ageing on serotonin transporters in healthy females.

J T Kuikka1, L Tammela, K A Bergström, L Karhunen, M Uusitupa, J Tiihonen.   

Abstract

The effect of ageing on brain serotonin transporters was evaluated in 19 healthy female volunteers (age range 22-74 years) using single-photon emission tomography and [123I]nor-beta-CIT. The study subjects were scanned 0.3, 3, 6 and 23 h after injection of 185 MBq of [123I]nor-beta-CIT. The ratio of the distribution volume for tracer in the midbrain to that in the cerebellum minus 1 was used as an index for serotonin transporter binding. An age-related decline of 2% per decade (r=-0.47; P<0.05) was found in the midbrain. The decline in [123I]nor-beta-CIT binding in the serotonin transporter-rich area is much less than that in dopamine transporters in the striatum (6% per decade).

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Year:  2001        PMID： 11504089     DOI： 10.1007/s002590100540

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  7 in total

1.  Treatment improves serotonin transporter binding and reduces binge eating.

Authors:  Liisa I Tammela; Aila Rissanen; Jyrki T Kuikka; Leila J Karhunen; Kim A Bergström; Eila Repo-Tiihonen; Hannu Naukkarinen; Esko Vanninen; Jari Tiihonen; Matti Uusitupa
Journal:  Psychopharmacology (Berl)       Date:  2003-05-27       Impact factor: 4.530

Review 2.  Neuromodulation of reward-based learning and decision making in human aging.

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Journal:  Ann N Y Acad Sci       Date:  2011-10       Impact factor: 5.691

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Journal:  Eur J Nucl Med Mol Imaging       Date:  2003-01-16       Impact factor: 9.236

4.  Positron emission tomography quantification of serotonin transporter in suicide attempters with major depressive disorder.

Authors:  Jeffrey M Miller; Natalie Hesselgrave; R Todd Ogden; Gregory M Sullivan; Maria A Oquendo; J John Mann; Ramin V Parsey
Journal:  Biol Psychiatry       Date:  2013-03-01       Impact factor: 13.382

5.  Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls.

Authors:  Walter Koch; Marcus Unterrainer; Guoming Xiong; Peter Bartenstein; Markus Diemling; Andrea Varrone; John C Dickson; Livia Tossici-Bolt; Terez Sera; Susanne Asenbaum; Jan Booij; Ozlem L Kapucu; Andreas Kluge; Morten Ziebell; Jacques Darcourt; Flavio Nobili; Marco Pagani; Swen Hesse; Thierry Vander Borght; Koen Van Laere; Klaus Tatsch; Christian la Fougère
Journal:  Eur J Nucl Med Mol Imaging       Date:  2014-05-08       Impact factor: 9.236

6.  Serotonin modulation of cerebral glucose metabolism: sex and age effects.

Authors:  Cynthia A Munro; Clifford I Workman; Elisse Kramer; Carol Hermann; Yilong Ma; Vijay Dhawan; Thomas Chaly; David Eidelberg; Gwenn S Smith
Journal:  Synapse       Date:  2012-08-28       Impact factor: 2.562

7.  A new model for separation between brain dopamine and serotonin transporters in 123I-beta-CIT SPECT measurements: normal values and sex and age dependence.

Authors:  Erik Ryding; Mats Lindström; Björn Brådvik; Martin Grabowski; Peter Bosson; Lil Träskman-Bendz; Ingmar Rosén
Journal:  Eur J Nucl Med Mol Imaging       Date:  2004-03-11       Impact factor: 9.236
  7 in total

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