Literature DB >> 12757959

Production of landomycins in Streptomyces globisporus 1912 and S cyanogenus S136 is regulated by genes encoding putative transcriptional activators.

Y Rebets1, B Ostash, A Luzhetskyy, D Hoffmeister, A Brana, C Mendez, J A Salas, A Bechthold, V Fedorenko.   

Abstract

The regulatory genes lanI and lndI have been cloned from the landomycin A (LaA) producer Streptomyces cyanogenus S136 and from the landomycin E (LaE) producer Streptomyces globisporus 1912, respectively and both have been sequenced. A culture of S. globisporus I2-1 carrying a disrupted lndI gene did not produce LaE and other related intermediates. Complementation of S. globisporus I2-1 with either the lndI or lanI gene reconstituted LaE production indicating that LanI and LndI are involved in activation of structural genes in the respective clusters. Structural features of these regulatory genes are discussed.

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Year:  2003        PMID： 12757959     DOI： 10.1016/S0378-1097(03)00258-1

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  19 in total

Review 1.  The TetR family of transcriptional repressors.

Authors:  Juan L Ramos; Manuel Martínez-Bueno; Antonio J Molina-Henares; Wilson Terán; Kazuya Watanabe; Xiaodong Zhang; María Trinidad Gallegos; Richard Brennan; Raquel Tobes
Journal:  Microbiol Mol Biol Rev       Date:  2005-06       Impact factor: 11.056

2.  On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2).

Authors:  Irfan Baig; Madan Kharel; Anton Kobylyanskyy; Lili Zhu; Yuriy Rebets; Bohdan Ostash; Andriy Luzhetskyy; Andreas Bechthold; Victor A Fedorenko; Jürgen Rohr
Journal:  Angew Chem Int Ed Engl       Date:  2006-11-27       Impact factor: 15.336

3.  Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone.

Authors:  Lili Zhu; Bohdan Ostash; Uwe Rix; Mohammad Nur-E-Alam; Almuth Mayers; Andriy Luzhetskyy; Carmen Mendez; Jose A Salas; Andreas Bechthold; Victor Fedorenko; Jürgen Rohr
Journal:  J Org Chem       Date:  2005-01-21       Impact factor: 4.354

4.  Activation of anthrachamycin biosynthesis in Streptomyces chattanoogensis L10 by site-directed mutagenesis of rpoB.

Authors:  Zi-Yue Li; Qing-Ting Bu; Jue Wang; Yu Liu; Xin-Ai Chen; Xu-Ming Mao; Yong-Quan Li
Journal:  J Zhejiang Univ Sci B       Date:  2019 Dec.       Impact factor: 3.066

5.  Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the duplicated type II polyketide synthase alp gene cluster in Streptomyces ambofaciens.

Authors:  Bertrand Aigle; Xiuhua Pang; Bernard Decaris; Pierre Leblond
Journal:  J Bacteriol       Date:  2005-04       Impact factor: 3.490

Review 6.  Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.

Authors:  Madan K Kharel; Jürgen Rohr
Journal:  Curr Opin Chem Biol       Date:  2012-03-30       Impact factor: 8.822

7.  Identification and characterization of the Streptomyces globisporus 1912 regulatory gene lndYR that affects sporulation and antibiotic production.

Authors:  Bohdan Ostash; Yuriy Rebets; Maksym Myronovskyy; Olga Tsypik; Iryna Ostash; Oleksandr Kulachkovskyy; Yuriy Datsyuk; Tatsunosuke Nakamura; Suzanne Walker; Victor Fedorenko
Journal:  Microbiology (Reading)       Date:  2011-02-03       Impact factor: 2.777

8.  Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136.

Authors:  Lili Zhu; Andriy Luzhetskyy; Martha Luzhetska; Cynthia Mattingly; Val Adams; Andreas Bechthold; Jürgen Rohr
Journal:  Chembiochem       Date:  2007-01-02       Impact factor: 3.164

9.  Identification and characterization of NocR as a positive transcriptional regulator of the beta-lactam nocardicin A in Nocardia uniformis.

Authors:  Jeanne M Davidsen; Craig A Townsend
Journal:  J Bacteriol       Date:  2008-11-21       Impact factor: 3.490

10.  Generation of landomycin D-producing strain Streptomyces globisporus LD3.

Authors:  B Ostash; I Kozarevska; V Fedorenko
Journal:  Folia Microbiol (Praha)       Date:  2005       Impact factor: 2.629
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