OBJECTIVE: To evaluate neuroendocrine changes in critical care patients with acute space occupying hemispheric stroke. METHODS: 22 patients with acute space occupying hemispheric stroke were studied (mean age 57.7 years; five women, 17 men). Plasma levels of prolactin, thyrotropin (TSH), total thyroxine (T4), free thyroxine (FT4), and total triiodothyronine (T3) were measured on admission and thereafter on days 3, 5, 7, and 9. Cortisol and ACTH levels were analysed at 8.00, 16.00, and 24.00 hours each day. A TRH stimulation test with measurements of TSH and prolactin was done on day 3. RESULTS: Nine patients underwent decompressive craniectomy and nine were treated with moderate hypothermia. All patients received vasopressor drugs because of arterial hypotension. Plasma ACTH and cortisol values were abnormally low despite systemic hypotension and acute systemic illness, and remained low throughout the observation period. The diurnal rhythm of cortisol was not preserved. Prolactin levels increased during the observation period, and were well above normal on day 9. Thyroid function was slightly suppressed until day 7. TRH stimulation of plasma TSH and prolactin was low. CONCLUSIONS: Patients with an acute space occupying cerebral infarct show profound neuroendocrine changes. The central regulation of adrenal and thyroid function and prolactin release is impaired, which may compromise the clinical course of affected patients and have implications for therapeutic management.
OBJECTIVE: To evaluate neuroendocrine changes in critical care patients with acute space occupying hemispheric stroke. METHODS: 22 patients with acute space occupying hemispheric stroke were studied (mean age 57.7 years; five women, 17 men). Plasma levels of prolactin, thyrotropin (TSH), total thyroxine (T4), free thyroxine (FT4), and total triiodothyronine (T3) were measured on admission and thereafter on days 3, 5, 7, and 9. Cortisol and ACTH levels were analysed at 8.00, 16.00, and 24.00 hours each day. A TRH stimulation test with measurements of TSH and prolactin was done on day 3. RESULTS: Nine patients underwent decompressive craniectomy and nine were treated with moderate hypothermia. All patients received vasopressor drugs because of arterial hypotension. Plasma ACTH and cortisol values were abnormally low despite systemic hypotension and acute systemic illness, and remained low throughout the observation period. The diurnal rhythm of cortisol was not preserved. Prolactin levels increased during the observation period, and were well above normal on day 9. Thyroid function was slightly suppressed until day 7. TRH stimulation of plasma TSH and prolactin was low. CONCLUSIONS:Patients with an acute space occupying cerebral infarct show profound neuroendocrine changes. The central regulation of adrenal and thyroid function and prolactin release is impaired, which may compromise the clinical course of affected patients and have implications for therapeutic management.
Authors: Hagen B Huttner; Ines-Christine Kiphuth; Linda Teuber; Hannes Lücking; Stephan P Kloska; Dimitre Staykov; Joji B Kuramatsu; Christoph Mauer; Lorenz Breuer; Arnd Doerfler; Martin Köhrmann Journal: Neurocrit Care Date: 2013-02 Impact factor: 3.210
Authors: Juan Antonio Llompart-Pou; Gerardo Pérez; Joan María Raurich; María Riesco; Marta Brell; Javier Ibáñez; Jon Pérez-Bárcena; Josep María Abadal; Javier Homar; Bartolomé Burguera Journal: Neurocrit Care Date: 2010-10 Impact factor: 3.210
Authors: Eyyup Sabri Seyhanli; Ugur Lok; Umut Gulacti; Hasan Buyukaslan; Metin Atescelik; Mustafa Yildiz; Mehmet Ruhi Onur; Mehmet Cagri Goktekin; Suleyman Aydın Journal: Int J Clin Exp Med Date: 2015-01-15
Authors: Amanda Jayne Barugh; Paul Gray; Susan Deborah Shenkin; Alasdair Maurice Joseph MacLullich; Gillian Elizabeth Mead Journal: J Neurol Date: 2014-01-30 Impact factor: 4.849