BACKGROUND: Traumatic brain injury (TBI) is commonly associated with disturbances of the hypothalamic-pituitary-adrenal axis secretion. Cerebral microdialysis techniques have been recently applied to measure brain interstitial cortisol levels. METHODS: We evaluated for the first time the circadian rhythm of cortisol secretion at 08:00, 16:00, and 24:00 h in the acute phase of TBI by determination of total serum and brain interstitial cortisol levels (microdialysis samples) in 10 patients with TBI. Non-parametric Friedman's two way analysis of variance test was used. RESULTS: Mean age was 29.8 ± 13.6 years. Median Glasgow Coma Scale score after resuscitation was 5 (range 3-10). No differences were found in total serum (P = 0.26) and brain interstitial cortisol (P = 0.77) in the whole sample. Intraindividual analysis showed that circadian variability was lost in all patients, both in serum and brain interstitial cortisol samples in the acute phase after TBI. CONCLUSION: In our series, circadian variability of cortisol evaluated by serum and cerebral microdialysis samples seems to be lost in TBI patients.
BACKGROUND:Traumatic brain injury (TBI) is commonly associated with disturbances of the hypothalamic-pituitary-adrenal axis secretion. Cerebral microdialysis techniques have been recently applied to measure brain interstitial cortisol levels. METHODS: We evaluated for the first time the circadian rhythm of cortisol secretion at 08:00, 16:00, and 24:00 h in the acute phase of TBI by determination of total serum and brain interstitial cortisol levels (microdialysis samples) in 10 patients with TBI. Non-parametric Friedman's two way analysis of variance test was used. RESULTS: Mean age was 29.8 ± 13.6 years. Median Glasgow Coma Scale score after resuscitation was 5 (range 3-10). No differences were found in total serum (P = 0.26) and brain interstitial cortisol (P = 0.77) in the whole sample. Intraindividual analysis showed that circadian variability was lost in all patients, both in serum and brain interstitial cortisol samples in the acute phase after TBI. CONCLUSION: In our series, circadian variability of cortisol evaluated by serum and cerebral microdialysis samples seems to be lost in TBI patients.
Authors: J A Llompart-Pou; G Pérez; J Pérez-Bárcena; M Brell; J Ibáñez; M Riesco; J M Abadal; J Homar; P Marsé; J Ibáñez; B Burguera; J M Raurich Journal: J Endocrinol Invest Date: 2010-06 Impact factor: 4.256
Authors: Susan L Bratton; Randall M Chestnut; Jamshid Ghajar; Flora F McConnell Hammond; Odette A Harris; Roger Hartl; Geoffrey T Manley; Andrew Nemecek; David W Newell; Guy Rosenthal; Joost Schouten; Lori Shutter; Shelly D Timmons; Jamie S Ullman; Walter Videtta; Jack E Wilberger; David W Wright Journal: J Neurotrauma Date: 2007 Impact factor: 5.269
Authors: Pejman Cohan; Christina Wang; David L McArthur; Shon W Cook; Joshua R Dusick; Bob Armin; Ronald Swerdloff; Paul Vespa; Jan Paul Muizelaar; Henry Gill Cryer; Peter D Christenson; Daniel F Kelly Journal: Crit Care Med Date: 2005-10 Impact factor: 7.598
Authors: Juan A Llompart-Pou; Joan M Raurich; Jon Pérez-Bárcena; Antonia Barceló; Jordi Ibáñez; José I Ayestarán Journal: Neurocrit Care Date: 2008 Impact factor: 3.210
Authors: Jeremy Cohen; Renae Deans; Andrew Dalley; Jeff Lipman; Michael S Roberts; Bala Venkatesh Journal: Crit Care Date: 2009-11-27 Impact factor: 9.097
Authors: Hagen B Huttner; Ines-Christine Kiphuth; Linda Teuber; Hannes Lücking; Stephan P Kloska; Dimitre Staykov; Joji B Kuramatsu; Christoph Mauer; Lorenz Breuer; Arnd Doerfler; Martin Köhrmann Journal: Neurocrit Care Date: 2013-02 Impact factor: 3.210
Authors: Amy K Wagner; Emily H McCullough; Christian Niyonkuru; Haishin Ozawa; Tammy L Loucks; Julie A Dobos; Christopher A Brett; Martina Santarsieri; C Edward Dixon; Sarah L Berga; Anthony Fabio Journal: J Neurotrauma Date: 2011-06-01 Impact factor: 5.269
Authors: Deborah R Boone; Stacy L Sell; Maria-Adelaide Micci; Jeanna M Crookshanks; Margaret Parsley; Tatsuo Uchida; Donald S Prough; Douglas S DeWitt; Helen L Hellmich Journal: PLoS One Date: 2012-10-03 Impact factor: 3.240