Literature DB >> 12754247

Error-prone polymerase, DNA polymerase IV, is responsible for transient hypermutation during adaptive mutation in Escherichia coli.

Joshua D Tompkins1, Jennifer L Nelson, Jill C Hazel, Stacy L Leugers, Jeffrey D Stumpf, Patricia L Foster.   

Abstract

The frequencies of nonselected mutations among adaptive Lac(+) revertants of Escherichia coli strains with and without the error-prone DNA polymerase IV (Pol IV) were compared. This frequency was more than sevenfold lower in the Pol IV-defective strain than in the wild-type strain. Thus, the mutations that occur during hypermutation are due to Pol IV.

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Year:  2003        PMID： 12754247      PMCID： PMC155394          DOI： 10.1128/JB.185.11.3469-3472.2003

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  45 in total

1.  Some features of the mutability of bacteria during nonlethal selection.

Authors:  V G Godoy; F S Gizatullin; M S Fox
Journal:  Genetics       Date:  2000-01       Impact factor: 4.562

2.  Role of the dinB gene product in spontaneous mutation in Escherichia coli with an impaired replicative polymerase.

Authors:  B S Strauss; R Roberts; L Francis; P Pouryazdanparast
Journal:  J Bacteriol       Date:  2000-12       Impact factor: 3.490

3.  The role of transient hypermutators in adaptive mutation in Escherichia coli.

Authors:  W A Rosche; P L Foster
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-08       Impact factor: 11.205

4.  Evidence that gene amplification underlies adaptive mutability of the bacterial lac operon.

Authors:  D I Andersson; E S Slechta; J R Roth
Journal:  Science       Date:  1998-11-06       Impact factor: 47.728

5.  Adaptive mutation of a lacZ amber allele.

Authors:  P L Foster; J Cairns
Journal:  Genetics       Date:  1998-11       Impact factor: 4.562

Review 6.  Mutation and cancer: the antecedents to our studies of adaptive mutation.

Authors:  J Cairns
Journal:  Genetics       Date:  1998-04       Impact factor: 4.562

7.  Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation.

Authors:  J Torkelson; R S Harris; M J Lombardo; J Nagendran; C Thulin; S M Rosenberg
Journal:  EMBO J       Date:  1997-06-02       Impact factor: 11.598

8.  Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis.

Authors:  M Tang; P Pham; X Shen; J S Taylor; M O'Donnell; R Woodgate; M F Goodman
Journal:  Nature       Date:  2000-04-27       Impact factor: 49.962

9.  Escherichia coli DNA polymerase IV mutator activity: genetic requirements and mutational specificity.

Authors:  J Wagner; T Nohmi
Journal:  J Bacteriol       Date:  2000-08       Impact factor: 3.490

10.  dinP, a new gene in Escherichia coli, whose product shows similarities to UmuC and its homologues.

Authors:  H Ohmori; E Hatada; Y Qiao; M Tsuji; R Fukuda
Journal:  Mutat Res       Date:  1995-06       Impact factor: 2.433
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  37 in total

1.  Adaptive mutation: general mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac.

Authors:  E Susan Slechta; Kim L Bunny; Elisabeth Kugelberg; Eric Kofoid; Dan I Andersson; John R Roth
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-14       Impact factor: 11.205

2.  Role of Escherichia coli DNA polymerase IV in in vivo replication fidelity.

Authors:  Wojciech Kuban; Piotr Jonczyk; Damian Gawel; Karolina Malanowska; Roel M Schaaper; Iwona J Fijalkowska
Journal:  J Bacteriol       Date:  2004-07       Impact factor: 3.490

3.  Adaptive point mutation and adaptive amplification pathways in the Escherichia coli Lac system: stress responses producing genetic change.

Authors:  Susan M Rosenberg; P J Hastings
Journal:  J Bacteriol       Date:  2004-08       Impact factor: 3.490

4.  Adaptive mutation in Escherichia coli.

Authors:  Patricia L Foster
Journal:  J Bacteriol       Date:  2004-08       Impact factor: 3.490

5.  Adaptive mutation: how growth under selection stimulates Lac(+) reversion by increasing target copy number.

Authors:  John R Roth; Dan I Andersson
Journal:  J Bacteriol       Date:  2004-08       Impact factor: 3.490

6.  Polymerases leave fingerprints: analysis of the mutational spectrum in Escherichia coli rpoB to assess the role of polymerase IV in spontaneous mutation.

Authors:  Erika Wolff; Mandy Kim; Kaibin Hu; Hanjing Yang; Jeffrey H Miller
Journal:  J Bacteriol       Date:  2004-05       Impact factor: 3.490

7.  Error-prone DNA polymerase IV is controlled by the stress-response sigma factor, RpoS, in Escherichia coli.

Authors:  Jill C Layton; Patricia L Foster
Journal:  Mol Microbiol       Date:  2003-10       Impact factor: 3.501

Review 8.  Stress responses and genetic variation in bacteria.

Authors:  Patricia L Foster
Journal:  Mutat Res       Date:  2005-01-06       Impact factor: 2.433

9.  SOS-independent induction of dinB transcription by beta-lactam-mediated inhibition of cell wall synthesis in Escherichia coli.

Authors:  Tatiana Pérez-Capilla; María-Rosario Baquero; José-María Gómez-Gómez; Alina Ionel; Soledad Martín; Jesús Blázquez
Journal:  J Bacteriol       Date:  2005-02       Impact factor: 3.490

10.  Mutator phenotype resulting from DNA polymerase IV overproduction in Escherichia coli: preferential mutagenesis on the lagging strand.

Authors:  Wojciech Kuban; Magdalena Banach-Orlowska; Malgorzata Bialoskorska; Aleksandra Lipowska; Roel M Schaaper; Piotr Jonczyk; Iwona J Fijalkowska
Journal:  J Bacteriol       Date:  2005-10       Impact factor: 3.490
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