Literature DB >> 12733752

Whole-body utilization of n-3 PUFA in n-6 PUFA-deficient rats.

Richard P Bazinet1, Holly Douglas, Stephen C Cunnane.   

Abstract

We evaluated the utilization of a-linolenic acid (18:3n-3) in growing rats consuming a diet deficient in n-6 PUFA. After 90 d, whole-body 18:3n-3 accumulation was 55% lower, total n-3 PUFA accumulation was 21% lower, and 18:3n-3 disappearance was 14% higher in n-6 PUFA-deficient rats. Part of the reduction of whole-body 18:3n-3 in n-6 PUFA-deficient rats was due to the 25% increase in net conversion of 18:3n-3 to long-chain n-3 PUFA. Despite adequate 18:3n-3 intake, n-6 PUFA deficiency decreased the accumulation of 18:3n-3 and total n-3 PUFA.

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Year:  2003        PMID： 12733752     DOI： 10.1007/s11745-003-1050-8

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  13 in total

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Authors:  H MOHRHAUER; R T HOLMAN
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2.  A simple method for the isolation and purification of total lipides from animal tissues.

Authors:  J FOLCH; M LEES; G H SLOANE STANLEY
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Authors:  S M GREENBERG; C E CALBERT; E E SAVAGE; H J DEUEL
Journal:  J Nutr       Date:  1950-07       Impact factor: 4.798

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Authors:  S C Cunnane; M J Anderson
Journal:  J Lipid Res       Date:  1997-04       Impact factor: 5.922

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Authors:  W E Lands; A Morris; B Libelt
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Review 6.  The conditional nature of the dietary need for polyunsaturates: a proposal to reclassify 'essential fatty acids' as 'conditionally-indispensable' or 'conditionally-dispensable' fatty acids.

Authors:  S C Cunnane
Journal:  Br J Nutr       Date:  2000-12       Impact factor: 3.718

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Authors:  W E Lands; B Libelt; A Morris; N C Kramer; T E Prewitt; P Bowen; D Schmeisser; M H Davidson; J H Burns
Journal:  Biochim Biophys Acta       Date:  1992-12-10

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Authors:  J Yang; Z Y Chen; S C Cunnane
Journal:  Metabolism       Date:  1994-08       Impact factor: 8.694

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Journal:  Lipids       Date:  1983-10       Impact factor: 1.880
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Journal:  Lipids       Date:  2006-10       Impact factor: 1.880

6.  Brain phospholipid arachidonic acid half-lives are not altered following 15 weeks of N-3 polyunsaturated fatty acid adequate or deprived diet.

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  10 in total

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