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Literature DB >> 127165

Studies on the biological role of DNA methylation: inhibition of methylation and maturation of the bacteriophage phichi174 by nicotinamide.

Abstract

Nicotinamide was found to be a potent inhibitor of DNA methylation in vivo without interfering with protein or DNA synthesis. The inhibition of DNA methylation in a phage-infected cell resulted in a parallel decrease in the production of viable virus particles. In vitro experiments revealed that nicotinamide inhibits DNA methylase activity in a competitive fashion with respect to S-adenosylmethionine and non-competitively with respect to DNA. These results were interpreted to mean that DNA methylation is an essential step in the process of maturation of the bacteriophage phichi174.

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Year: 1975 PMID： 127165 PMCID： PMC343560 DOI： 10.1093/nar/2.10.1967

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

15 in total

1. The process of infection with bacteriophage phi-XI74. I. Evidence for a "replicative form".

Authors: R L SINSHEIMER; B STARMAN; C NAGLER; S GUTHRIE
Journal: J Mol Biol Date: 1962-03 Impact factor: 5.469

2. DNA methylase induced by bacteriophage phiX174.

Authors: A Razin
Journal: Proc Natl Acad Sci U S A Date: 1973-12 Impact factor: 11.205

3. In vivo methylation of replicating bacteriophage phi chi174 DNA.

Authors: A Razin; J W Sedat; R L Sinsheimer
Journal: J Mol Biol Date: 1973-08-15 Impact factor: 5.469

4. Kinetics and mechanisms of action of trimethoprim and sulfonamides, alone or in combination, upon Escherichia coli.

Authors: J K Seydel; E Wempe; G H Miller; L Miller
Journal: Chemotherapy Date: 1972 Impact factor: 2.544

5. Enzymatic methylations. II. In vitro inhibition of tRNA and protein methylation by nicotinamide and isonicotinic acid hydrazide: activation of a s-adenosylmethionine-splitting enzyme in rat liver.

Authors: H J Gross; D Wildenauer
Journal: Biochem Biophys Res Commun Date: 1972-07-11 Impact factor: 3.575

6. Inhibition of transfer ribonucleic acid methylase activity from several human tumors by nicotinamide and nicotinamide analogs.

Authors: L Buch; D Streeter; R M Halpern; L N Simon; M G Stout; R A Smith
Journal: Biochemistry Date: 1972-02-01 Impact factor: 3.162

Review 7. DNA modification and restriction.

Authors: W Arber; S Linn
Journal: Annu Rev Biochem Date: 1969 Impact factor: 23.643

8. Isolation of deoxyribonucleic acid methylase mutants of Escherichia coli K-12.

Authors: M G Marinus; N R Morris
Journal: J Bacteriol Date: 1973-06 Impact factor: 3.490

9. Regulatory properties of adenosine triphosphate-L-methionine S-adenosyltransferase of rat liver.

Authors: J B Lombardini; T C Chou; P Talalay
Journal: Biochem J Date: 1973-09 Impact factor: 3.857

10. Location of the 5-methylcytosine group on the bacteriophage phi X174 genome.

Authors: A S Lee; R L Sinsheimer
Journal: J Virol Date: 1974-10 Impact factor: 5.103

9 in total

1. Studies on the biological role of DNA methylation: III Role in excision of one-genome long single-stranded phi X 174 DNA.

Authors: J Friedman; A Friedmann; A Razin
Journal: Nucleic Acids Res Date: 1977-10 Impact factor: 16.971

2. Studies on the biological role of DNA methylation. II. Role of phiX174 DNA methylation in the process of viral progeny DNA synthesis.

Authors: J Friedman; A Razin
Journal: Nucleic Acids Res Date: 1976-10 Impact factor: 16.971

Studies on the biological role of DNA methylation: inhibition of methylation and maturation of the bacteriophage phichi174 by nicotinamide.

1. The process of infection with bacteriophage phi-XI74. I. Evidence for a "replicative form".

2. DNA methylase induced by bacteriophage phiX174.

3. In vivo methylation of replicating bacteriophage phi chi174 DNA.

4. Kinetics and mechanisms of action of trimethoprim and sulfonamides, alone or in combination, upon Escherichia coli.

5. Enzymatic methylations. II. In vitro inhibition of tRNA and protein methylation by nicotinamide and isonicotinic acid hydrazide: activation of a s-adenosylmethionine-splitting enzyme in rat liver.

6. Inhibition of transfer ribonucleic acid methylase activity from several human tumors by nicotinamide and nicotinamide analogs.

Review 7. DNA modification and restriction.

8. Isolation of deoxyribonucleic acid methylase mutants of Escherichia coli K-12.

9. Regulatory properties of adenosine triphosphate-L-methionine S-adenosyltransferase of rat liver.

10. Location of the 5-methylcytosine group on the bacteriophage phi X174 genome.

1. Studies on the biological role of DNA methylation: III Role in excision of one-genome long single-stranded phi X 174 DNA.

2. Studies on the biological role of DNA methylation. II. Role of phiX174 DNA methylation in the process of viral progeny DNA synthesis.

3. Distribution of 5-methylcytosine in chromatin.

Review 4. Bacteriophage T3 and bacteriophage T7 virus-host cell interactions.

5. A Low Molecular Weight Polypeptide Which Accumulates upon Inhibition of Porphyrin Biosynthesis in Maize.

6. Kinetics of methylation in Escherichia coli K-12.

7. Studies on the biological role of DNA methylation: V. The pattern of E.coli DNA methylation.

8. DNA-methylase from regenerating rat liver: purification and characterisation.

9. In vivo methylation of bacteriophage phi X174 DNA.