AIMS/HYPOTHESIS: Diets rich in insoluble-fibre are linked to a reduced risk of both diabetes and cardiovascular disease; however, the mechanism of action remains unclear. The aim of this study was to assess whether acute changes in the insoluble-fibre (resistant starch) content of the diet would have effects on postprandial carbohydrate and lipid handling. METHODS: Ten healthy subjects consumed two identical, low-residue diets on separate occasions for 24 h (33% fat; <2 g dietary fibre). Of the diets one was supplemented with 60 g resistant starch (Novelose 260). On the following morning a fibre-free meal tolerance test (MTT) was carried out (59 g carbohydrate; 21 g fat; 2.1 kJ) and postprandial insulin sensitivity (SI(ORAL)) assessed using a minimal model approach. RESULTS: Prior resistant starch consumption led to lower postprandial plasma glucose (p=0.037) and insulin (p=0.038) with a higher insulin sensitivity(44+/-7.5 vs 26+/-3.5 x 10(-4) dl kg(-1) min(-1) per micro Uml(-1); p=0.028) and C-peptide-to-insulin molar ratio (18.7+/-6.5 vs 9.7+/-0.69; p=0.017). There was no effect of resistant starch consumption on plasma triacylglycerol although non-esterified fatty acid and 3-hydroxybutyrate levels were suppressed 5 h after the meal tolerance test. CONCLUSION: Prior acute consumption of a high-dose of resistant starch enhanced carbohydrate handling in the postprandial period the following day potentially due to the increased rate of colonic fermentation.
AIMS/HYPOTHESIS: Diets rich in insoluble-fibre are linked to a reduced risk of both diabetes and cardiovascular disease; however, the mechanism of action remains unclear. The aim of this study was to assess whether acute changes in the insoluble-fibre (resistant starch) content of the diet would have effects on postprandial carbohydrate and lipid handling. METHODS: Ten healthy subjects consumed two identical, low-residue diets on separate occasions for 24 h (33% fat; <2 g dietary fibre). Of the diets one was supplemented with 60 g resistant starch (Novelose 260). On the following morning a fibre-free meal tolerance test (MTT) was carried out (59 g carbohydrate; 21 g fat; 2.1 kJ) and postprandial insulin sensitivity (SI(ORAL)) assessed using a minimal model approach. RESULTS: Prior resistant starch consumption led to lower postprandial plasma glucose (p=0.037) and insulin (p=0.038) with a higher insulin sensitivity(44+/-7.5 vs 26+/-3.5 x 10(-4) dl kg(-1) min(-1) per micro Uml(-1); p=0.028) and C-peptide-to-insulin molar ratio (18.7+/-6.5 vs 9.7+/-0.69; p=0.017). There was no effect of resistant starch consumption on plasma triacylglycerol although non-esterified fatty acid and 3-hydroxybutyrate levels were suppressed 5 h after the meal tolerance test. CONCLUSION: Prior acute consumption of a high-dose of resistant starch enhanced carbohydrate handling in the postprandial period the following day potentially due to the increased rate of colonic fermentation.
Authors: Kara L Marlatt; Ursula A White; Robbie A Beyl; Courtney M Peterson; Corby K Martin; Maria L Marco; Michael J Keenan; Roy J Martin; Kayanush J Aryana; Eric Ravussin Journal: Contemp Clin Trials Date: 2017-12-21 Impact factor: 2.226
Authors: M O Weickert; M Mohlig; C Koebnick; J J Holst; P Namsolleck; M Ristow; M Osterhoff; H Rochlitz; N Rudovich; J Spranger; A F H Pfeiffer Journal: Diabetologia Date: 2005-09-20 Impact factor: 10.122
Authors: Elin V Johansson Boll; Linda M N K Ekström; Christophe M Courtin; Jan A Delcour; Anne C Nilsson; Inger M E Björck; Elin M Östman Journal: Eur J Nutr Date: 2015-07-14 Impact factor: 5.614
Authors: Ursula White; Courtney M Peterson; Robbie A Beyl; Corby K Martin; Eric Ravussin Journal: J Acad Nutr Diet Date: 2020-04-09 Impact factor: 4.910
Authors: Courtney M Peterson; Robbie A Beyl; Kara L Marlatt; Corby K Martin; Kayanush J Aryana; Maria L Marco; Roy J Martin; Michael J Keenan; Eric Ravussin Journal: Am J Clin Nutr Date: 2018-09-01 Impact factor: 7.045