Literature DB >> 12700276

Essentiality of clpX, but not clpP, clpL, clpC, or clpE, in Streptococcus pneumoniae R6.

Gregory T Robertson1, Wai-Leung Ng, Raymond Gilmour, Malcolm E Winkler.   

Abstract

We show by using a regulated promoter that clpX of Streptococcus pneumoniae R6 is essential, whereas clpP, clpL, clpC, and clpE can be disrupted. The essentiality of clpX was initially missed because of duplication and rearrangement in the region of the chromosome containing clpX. Depletion of ClpX resulted in a rapid loss of viability without overt changes in cell morphology. Essentiality of clpX, but not clpP, has not been reported previously.

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Year:  2003        PMID： 12700276      PMCID： PMC154392          DOI： 10.1128/JB.185.9.2961-2966.2003

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  35 in total

1.  Construction of a tightly regulated plasmid vector for Streptococcus pneumoniae: controlled expression of the green fluorescent protein.

Authors:  C Nieto; P Fernández de Palencia; P López; M Espinosa
Journal:  Plasmid       Date:  2000-05       Impact factor: 3.466

2.  The Streptococcus pneumoniae beta-galactosidase is a surface protein.

Authors:  D Zähner; R Hakenbeck
Journal:  J Bacteriol       Date:  2000-10       Impact factor: 3.490

3.  Regulation of growth inhibition at high temperature, autolysis, transformation and adherence in Streptococcus pneumoniae by clpC.

Authors:  E Charpentier; R Novak; E Tuomanen
Journal:  Mol Microbiol       Date:  2000-08       Impact factor: 3.501

4.  Regulation of Streptococcus pneumoniae clp genes and their role in competence development and stress survival.

Authors:  A Chastanet; M Prudhomme; J P Claverys; T Msadek
Journal:  J Bacteriol       Date:  2001-12       Impact factor: 3.490

5.  Precise amounts of a novel member of a phosphotransferase superfamily are essential for growth and normal morphology in Caulobacter crescentus.

Authors:  T Fuchs; P Wiget; M Osterås; U Jenal
Journal:  Mol Microbiol       Date:  2001-02       Impact factor: 3.501

6.  Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.

Authors:  H Tettelin; K E Nelson; I T Paulsen; J A Eisen; T D Read; S Peterson; J Heidelberg; R T DeBoy; D H Haft; R J Dodson; A S Durkin; M Gwinn; J F Kolonay; W C Nelson; J D Peterson; L A Umayam; O White; S L Salzberg; M R Lewis; D Radune; E Holtzapple; H Khouri; A M Wolf; T R Utterback; C L Hansen; L A McDonald; T V Feldblyum; S Angiuoli; T Dickinson; E K Hickey; I E Holt; B J Loftus; F Yang; H O Smith; J C Venter; B A Dougherty; D A Morrison; S K Hollingshead; C M Fraser
Journal:  Science       Date:  2001-07-20       Impact factor: 47.728

7.  Identification of a new regulator in Streptococcus pneumoniae linking quorum sensing to competence for genetic transformation.

Authors:  M S Lee; D A Morrison
Journal:  J Bacteriol       Date:  1999-08       Impact factor: 3.490

8.  Genome of the bacterium Streptococcus pneumoniae strain R6.

Authors:  J Hoskins; W E Alborn; J Arnold; L C Blaszczak; S Burgett; B S DeHoff; S T Estrem; L Fritz; D J Fu; W Fuller; C Geringer; R Gilmour; J S Glass; H Khoja; A R Kraft; R E Lagace; D J LeBlanc; L N Lee; E J Lefkowitz; J Lu; P Matsushima; S M McAhren; M McHenney; K McLeaster; C W Mundy; T I Nicas; F H Norris; M O'Gara; R B Peery; G T Robertson; P Rockey; P M Sun; M E Winkler; Y Yang; M Young-Bellido; G Zhao; C A Zook; R H Baltz; S R Jaskunas; P R Rosteck; P L Skatrud; J I Glass
Journal:  J Bacteriol       Date:  2001-10       Impact factor: 3.490

9.  An rpsL cassette, janus, for gene replacement through negative selection in Streptococcus pneumoniae.

Authors:  C K Sung; H Li; J P Claverys; D A Morrison
Journal:  Appl Environ Microbiol       Date:  2001-11       Impact factor: 4.792

10.  Global transcriptional analysis of clpP mutations of type 2 Streptococcus pneumoniae and their effects on physiology and virulence.

Authors:  Gregory T Robertson; Wai-Leung Ng; Joseph Foley; Raymond Gilmour; Malcolm E Winkler
Journal:  J Bacteriol       Date:  2002-07       Impact factor: 3.490
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  15 in total

1.  Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6.

Authors:  Joel A Lanie; Wai-Leung Ng; Krystyna M Kazmierczak; Tiffany M Andrzejewski; Tanja M Davidsen; Kyle J Wayne; Hervé Tettelin; John I Glass; Malcolm E Winkler
Journal:  J Bacteriol       Date:  2006-10-13       Impact factor: 3.490

2.  Competence for genetic transformation in Streptococcus pneumoniae: termination of activity of the alternative sigma factor ComX is independent of proteolysis of ComX and ComW.

Authors:  Andrew Piotrowski; Ping Luo; Donald A Morrison
Journal:  J Bacteriol       Date:  2009-03-13       Impact factor: 3.490

3.  The Protease Locus of Francisella tularensis LVS Is Required for Stress Tolerance and Infection in the Mammalian Host.

Authors:  Lihong He; Manoj Kumar Mohan Nair; Yuling Chen; Xue Liu; Mengyun Zhang; Karsten R O Hazlett; Haiteng Deng; Jing-Ren Zhang
Journal:  Infect Immun       Date:  2016-04-22       Impact factor: 3.441

4.  Virulence attenuation of Streptococcus pneumoniae clpP mutant by sensitivity to oxidative stress in macrophages via an NO-mediated pathway.

Authors:  Chul-Yong Park; Eun-Hye Kim; Sang-Yoon Choi; Thao Dang-Hien Tran; In-Hye Kim; Su-Nam Kim; Suhkneung Pyo; Dong-Kwon Rhee
Journal:  J Microbiol       Date:  2010-05-01       Impact factor: 3.422

5.  Effect of nonheme iron-containing ferritin Dpr in the stress response and virulence of pneumococci.

Authors:  Chun-Zhen Hua; Angela Howard; Richard Malley; Ying-Jie Lu
Journal:  Infect Immun       Date:  2014-07-07       Impact factor: 3.441

6.  Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans.

Authors:  Jessica K Kajfasz; Isamar Rivera-Ramos; Jacqueline Abranches; Alaina R Martinez; Pedro L Rosalen; Adam M Derr; Robert G Quivey; José A Lemos
Journal:  J Bacteriol       Date:  2010-03-16       Impact factor: 3.490

7.  The requirement for pneumococcal MreC and MreD is relieved by inactivation of the gene encoding PBP1a.

Authors:  Adrian D Land; Malcolm E Winkler
Journal:  J Bacteriol       Date:  2011-06-17       Impact factor: 3.490

8.  Role of Clp proteins in expression of virulence properties of Streptococcus mutans.

Authors:  Jessica K Kajfasz; Alaina R Martinez; Isamar Rivera-Ramos; Jacqueline Abranches; Hyun Koo; Robert G Quivey; José A Lemos
Journal:  J Bacteriol       Date:  2009-01-30       Impact factor: 3.490

9.  ClpXP degrades SsrA-tagged proteins in Streptococcus pneumoniae.

Authors:  Sarita Ahlawat; Donald A Morrison
Journal:  J Bacteriol       Date:  2009-02-13       Impact factor: 3.490

Review 10.  Stress Physiology of Lactic Acid Bacteria.

Authors:  Konstantinos Papadimitriou; Ángel Alegría; Peter A Bron; Maria de Angelis; Marco Gobbetti; Michiel Kleerebezem; José A Lemos; Daniel M Linares; Paul Ross; Catherine Stanton; Francesca Turroni; Douwe van Sinderen; Pekka Varmanen; Marco Ventura; Manuel Zúñiga; Effie Tsakalidou; Jan Kok
Journal:  Microbiol Mol Biol Rev       Date:  2016-07-27       Impact factor: 11.056
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