Literature DB >> 12692467

Role of MC4 receptors in the depressor and bradycardic effects of alpha-MSH in the nucleus tractus solitarii of the rat.

Jillian M Pavia1, Helgi B Schiöth, Margaret J Morris.   

Abstract

The receptor subtype(s) responsible for the cardiovascular actions of the melanocortins remains to be elucidated. This study investigated the cardiovascular effects of central injection of alpha-MSH and a potent cyclic MC3/4 receptor agonist, MTII, in the presence and absence of the newly developed MC4 receptor selective antagonist, HS014. Both alpha-MSH (250 pmol) and MTII (20-500 pmol) produced a rapid decrease in blood pressure and heart rate after injection into the nucleus tractus solitarii (NTS) of urethane-anaesthetised male Sprague-Dawley rats. These responses were attenuated in a dose-dependent manner by prior local NTS blockade with HS014 (20 or 100 pmol), providing evidence for the role of the MC4 receptor in the cardiovascular changes following NTS injection of melanocortins in the rat.

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Year:  2003        PMID： 12692467     DOI： 10.1097/00001756-200304150-00009

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  8 in total

Review 1.  Role of the brain melanocortins in blood pressure regulation.

Authors:  Jussara M do Carmo; Alexandre A da Silva; Zhen Wang; Taolin Fang; Nicola Aberdein; Cecilia E Perez de Lara; John E Hall
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2017-03-06       Impact factor: 5.187

Review 2.  The brain melanocortin system, sympathetic control, and obesity hypertension.

Authors:  Alexandre A da Silva; Jussara M do Carmo; Zhen Wang; John E Hall
Journal:  Physiology (Bethesda)       Date:  2014-05

3.  Plasma neuropeptide Y (NPY) and alpha-melanocyte stimulating hormone (a-MSH) levels in patients with or without hypertension and/or obesity: a pilot study.

Authors:  Maria Baltazi; Niki Katsiki; Christos Savopoulos; Fotios Iliadis; George Koliakos; Apostolos I Hatzitolios
Journal:  Am J Cardiovasc Dis       Date:  2011-05-20

Review 4.  The Role of the Melanocortin System in Metabolic Disease: New Developments and Advances.

Authors:  Jennifer W Hill; Latrice D Faulkner
Journal:  Neuroendocrinology       Date:  2016-10-11       Impact factor: 4.914

5.  Microinjections of alpha-melanocyte stimulating hormone into the nucleus ambiguus of the rat elicit vagally mediated bradycardia.

Authors:  Vineet C Chitravanshi; Suresh Bhatt; Hreday N Sapru
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2009-03-18       Impact factor: 3.619

6.  Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneously hypertensive rats.

Authors:  Alexandre A da Silva; Jussara M do Carmo; Bela Kanyicska; John Dubinion; Elizabeth Brandon; John E Hall
Journal:  Hypertension       Date:  2008-02-19       Impact factor: 10.190

7.  Differential control of metabolic and cardiovascular functions by melanocortin-4 receptors in proopiomelanocortin neurons.

Authors:  Jussara M do Carmo; Alexandre A da Silva; John S Rushing; Benjamin Pace; John E Hall
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2013-07-10       Impact factor: 3.619

8.  Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques.

Authors:  Paul Kievit; Heather Halem; Daniel L Marks; Jesse Z Dong; Maria M Glavas; Puspha Sinnayah; Lindsay Pranger; Michael A Cowley; Kevin L Grove; Michael D Culler
Journal:  Diabetes       Date:  2012-10-09       Impact factor: 9.461
  8 in total

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